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Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential
The chronic nature of diabetes mellitus motivates the quest for novel agents to improve its management. The scarcity and prior uncontrolled utilization of medicinal plants have encouraged researchers to seek new sources of promising compounds. Recently, endophytes have presented as eco-friendly lead...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968060/ https://www.ncbi.nlm.nih.gov/pubmed/36838706 http://dx.doi.org/10.3390/molecules28041718 |
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author | AbdelRazek, Mohamed M. M. Elissawy, Ahmed M. Mostafa, Nada M. Moussa, Ashaimaa Y. Elanany, Mohamed A. Elshanawany, Mohamed A. Singab, Abdel Nasser B. |
author_facet | AbdelRazek, Mohamed M. M. Elissawy, Ahmed M. Mostafa, Nada M. Moussa, Ashaimaa Y. Elanany, Mohamed A. Elshanawany, Mohamed A. Singab, Abdel Nasser B. |
author_sort | AbdelRazek, Mohamed M. M. |
collection | PubMed |
description | The chronic nature of diabetes mellitus motivates the quest for novel agents to improve its management. The scarcity and prior uncontrolled utilization of medicinal plants have encouraged researchers to seek new sources of promising compounds. Recently, endophytes have presented as eco-friendly leading sources for bioactive metabolites. This article reviewed the endophytic fungi associated with Morus species and their isolated compounds, in addition to the biological activities tested on their extracts and chemical constituents. The relevant literature was collected from the years 2008–2022 from PubMed and Web of Science databases. Notably, no antidiabetic activity was reported for any of the Morus-associated endophytic fungal extracts or their twenty-one previously isolated compounds. This encouraged us to perform an in silico study on the previously isolated compounds to explore their possible antidiabetic potential. Furthermore, pharmacokinetic and dynamic stability studies were performed on these compounds. Upon molecular docking, Colletotrichalactone A (14) showed a promising antidiabetic activity due to the inhibition of the α-amylase local target and the human sodium-glucose cotransporter 2 (hSGT2) systemic target with safe pharmacokinetic features. These results provide an in silico interpretation of the possible anti-diabetic potential of Morus endophytic metabolites, yet further study is required. |
format | Online Article Text |
id | pubmed-9968060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99680602023-02-27 Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential AbdelRazek, Mohamed M. M. Elissawy, Ahmed M. Mostafa, Nada M. Moussa, Ashaimaa Y. Elanany, Mohamed A. Elshanawany, Mohamed A. Singab, Abdel Nasser B. Molecules Article The chronic nature of diabetes mellitus motivates the quest for novel agents to improve its management. The scarcity and prior uncontrolled utilization of medicinal plants have encouraged researchers to seek new sources of promising compounds. Recently, endophytes have presented as eco-friendly leading sources for bioactive metabolites. This article reviewed the endophytic fungi associated with Morus species and their isolated compounds, in addition to the biological activities tested on their extracts and chemical constituents. The relevant literature was collected from the years 2008–2022 from PubMed and Web of Science databases. Notably, no antidiabetic activity was reported for any of the Morus-associated endophytic fungal extracts or their twenty-one previously isolated compounds. This encouraged us to perform an in silico study on the previously isolated compounds to explore their possible antidiabetic potential. Furthermore, pharmacokinetic and dynamic stability studies were performed on these compounds. Upon molecular docking, Colletotrichalactone A (14) showed a promising antidiabetic activity due to the inhibition of the α-amylase local target and the human sodium-glucose cotransporter 2 (hSGT2) systemic target with safe pharmacokinetic features. These results provide an in silico interpretation of the possible anti-diabetic potential of Morus endophytic metabolites, yet further study is required. MDPI 2023-02-10 /pmc/articles/PMC9968060/ /pubmed/36838706 http://dx.doi.org/10.3390/molecules28041718 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article AbdelRazek, Mohamed M. M. Elissawy, Ahmed M. Mostafa, Nada M. Moussa, Ashaimaa Y. Elanany, Mohamed A. Elshanawany, Mohamed A. Singab, Abdel Nasser B. Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential |
title | Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential |
title_full | Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential |
title_fullStr | Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential |
title_full_unstemmed | Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential |
title_short | Chemical and Biological Review of Endophytic Fungi Associated with Morus sp. (Moraceae) and In Silico Study of Their Antidiabetic Potential |
title_sort | chemical and biological review of endophytic fungi associated with morus sp. (moraceae) and in silico study of their antidiabetic potential |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968060/ https://www.ncbi.nlm.nih.gov/pubmed/36838706 http://dx.doi.org/10.3390/molecules28041718 |
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