Transgenic Zebrafish Expressing Rat Cytochrome P450 2E1 (CYP2E1): Augmentation of Acetaminophen-Induced Toxicity in the Liver and Retina

Metabolic activation is the primary cause of chemical toxicity including hepatotoxicity. Cytochrome P450 2E (CYP2E) is involved in this process for many hepatotoxicants, including acetaminophen (APAP), one of the most common analgesics and antipyretics. Although the zebrafish is now used as a model...

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Detalles Bibliográficos
Autores principales: Sato, Yoshinori, Dong, Wenjing, Nakamura, Tatsuro, Mizoguchi, Naohiro, Nawaji, Tasuku, Nishikawa, Miyu, Onaga, Takenori, Ikushiro, Shinichi, Kobayashi, Makoto, Teraoka, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968093/
https://www.ncbi.nlm.nih.gov/pubmed/36835425
http://dx.doi.org/10.3390/ijms24044013

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