Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of Chlorinated N-arylcinnamamides

A series of seventeen 4-chlorocinnamanilides and seventeen 3,4-dichlorocinnamanilides were characterized for their antiplasmodial activity. In vitro screening on a chloroquine-sensitive strain of Plasmodium falciparum 3D7/MRA-102 highlighted that 23 compounds possessed IC(50) < 30 µM. Typically,...

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Detalles Bibliográficos
Autores principales: Bak, Andrzej, Kos, Jiri, Degotte, Gilles, Swietlicka, Aleksandra, Strharsky, Tomas, Pindjakova, Dominika, Gonec, Tomas, Smolinski, Adam, Francotte, Pierre, Frederich, Michel, Kozik, Violetta, Jampilek, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968098/
https://www.ncbi.nlm.nih.gov/pubmed/36835023
http://dx.doi.org/10.3390/ijms24043611

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