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Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases

Background: The role of surgery in the treatment of Graves’ disease (GD) needs to be revisited. The aims of the present retrospective study were to evaluate the outcomes of the current surgical strategy as a definitive treatment of GD at our center and to explore the clinical association between GD...

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Autores principales: Sun, Hanxing, Tong, Hui, Shen, Xiaohui, Gao, Haoji, Kuang, Jie, Chen, Xi, Li, Qinyu, Qiu, Weihua, Liu, Zhuoran, Yan, Jiqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968166/
https://www.ncbi.nlm.nih.gov/pubmed/36835843
http://dx.doi.org/10.3390/jcm12041308
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author Sun, Hanxing
Tong, Hui
Shen, Xiaohui
Gao, Haoji
Kuang, Jie
Chen, Xi
Li, Qinyu
Qiu, Weihua
Liu, Zhuoran
Yan, Jiqi
author_facet Sun, Hanxing
Tong, Hui
Shen, Xiaohui
Gao, Haoji
Kuang, Jie
Chen, Xi
Li, Qinyu
Qiu, Weihua
Liu, Zhuoran
Yan, Jiqi
author_sort Sun, Hanxing
collection PubMed
description Background: The role of surgery in the treatment of Graves’ disease (GD) needs to be revisited. The aims of the present retrospective study were to evaluate the outcomes of the current surgical strategy as a definitive treatment of GD at our center and to explore the clinical association between GD and thyroid cancer. Methods: A patient cohort of 216 cases from 2013 to 2020 was involved in this retrospective study. The data of the clinical characteristics and follow-up results were collected and analyzed. Results: There were 182 female and 34 male patients. The mean age was 43.9 ± 15.0 years old. The mean duration of GD reached 72.2 ± 92.7 months. Of the 216 cases, 211 had been treated with antithyroid drugs (ATDs) and hyperthyroidism had been completely controlled in 198 cases. A total (75%) or near-total (23.6%) thyroidectomy was performed. Intraoperative neural monitoring (IONM) was applied to 37 patients. The failure of ATD therapy (52.3%) was the most common surgical indication, followed by suspicion of a malignant nodule (45.8%). A total of 24 (11.1%) patients had hoarseness after the operation and 15 (6.9%) patients had transient vocal cord paralysis; 3 (1.4%) had this problem permanently. No bilateral RLN paralysis occurred. A total of 45 patients had hypoparathyroidism and 42 of them recovered within 6 months. Sex showed a correlation with hypoparathyroidism through a univariate analysis. A total of 2 (0.9%) patients underwent a reoperation because of hematomas. A total of 104 (48.1%) cases were diagnosed as thyroid cancer. In most cases (72.1%), the malignant nodules were microcarcinomas. A total of 38 patients had a central compartment node metastasis. A lateral lymph node metastasis occurred in 10 patients. Thyroid carcinomas were incidentally discovered in the specimens of 7 cases. The patients with concomitant thyroid cancer had a significant difference in body mass index, duration of GD, gland size, thyrotropin receptor antibodies and nodule(s) detected. Conclusion: Surgical treatments for GD were effective, with a relatively low incidence of complications at this high-volume center. Concomitant thyroid cancer is one of the most important surgical indications for GD patients. Careful ultrasonic screening is necessary to exclude the presence of malignancies and to determine the therapeutic plan.
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spelling pubmed-99681662023-02-27 Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases Sun, Hanxing Tong, Hui Shen, Xiaohui Gao, Haoji Kuang, Jie Chen, Xi Li, Qinyu Qiu, Weihua Liu, Zhuoran Yan, Jiqi J Clin Med Article Background: The role of surgery in the treatment of Graves’ disease (GD) needs to be revisited. The aims of the present retrospective study were to evaluate the outcomes of the current surgical strategy as a definitive treatment of GD at our center and to explore the clinical association between GD and thyroid cancer. Methods: A patient cohort of 216 cases from 2013 to 2020 was involved in this retrospective study. The data of the clinical characteristics and follow-up results were collected and analyzed. Results: There were 182 female and 34 male patients. The mean age was 43.9 ± 15.0 years old. The mean duration of GD reached 72.2 ± 92.7 months. Of the 216 cases, 211 had been treated with antithyroid drugs (ATDs) and hyperthyroidism had been completely controlled in 198 cases. A total (75%) or near-total (23.6%) thyroidectomy was performed. Intraoperative neural monitoring (IONM) was applied to 37 patients. The failure of ATD therapy (52.3%) was the most common surgical indication, followed by suspicion of a malignant nodule (45.8%). A total of 24 (11.1%) patients had hoarseness after the operation and 15 (6.9%) patients had transient vocal cord paralysis; 3 (1.4%) had this problem permanently. No bilateral RLN paralysis occurred. A total of 45 patients had hypoparathyroidism and 42 of them recovered within 6 months. Sex showed a correlation with hypoparathyroidism through a univariate analysis. A total of 2 (0.9%) patients underwent a reoperation because of hematomas. A total of 104 (48.1%) cases were diagnosed as thyroid cancer. In most cases (72.1%), the malignant nodules were microcarcinomas. A total of 38 patients had a central compartment node metastasis. A lateral lymph node metastasis occurred in 10 patients. Thyroid carcinomas were incidentally discovered in the specimens of 7 cases. The patients with concomitant thyroid cancer had a significant difference in body mass index, duration of GD, gland size, thyrotropin receptor antibodies and nodule(s) detected. Conclusion: Surgical treatments for GD were effective, with a relatively low incidence of complications at this high-volume center. Concomitant thyroid cancer is one of the most important surgical indications for GD patients. Careful ultrasonic screening is necessary to exclude the presence of malignancies and to determine the therapeutic plan. MDPI 2023-02-07 /pmc/articles/PMC9968166/ /pubmed/36835843 http://dx.doi.org/10.3390/jcm12041308 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Hanxing
Tong, Hui
Shen, Xiaohui
Gao, Haoji
Kuang, Jie
Chen, Xi
Li, Qinyu
Qiu, Weihua
Liu, Zhuoran
Yan, Jiqi
Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
title Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
title_full Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
title_fullStr Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
title_full_unstemmed Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
title_short Outcomes of Surgical Treatment for Graves’ Disease: A Single-Center Experience of 216 Cases
title_sort outcomes of surgical treatment for graves’ disease: a single-center experience of 216 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968166/
https://www.ncbi.nlm.nih.gov/pubmed/36835843
http://dx.doi.org/10.3390/jcm12041308
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