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Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy

Background: Data regarding the association between sleep apnea (SA) and atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) are still limited. We aim to investigate the association of both types of SA, obstructive sleep apnea (OSA) and central sleep apnea (CSA), and nocturnal hypoxemia wit...

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Autores principales: Xu, Haobo, Wang, Juan, Qiao, Shubin, Yuan, Jiansong, Hu, Fenghuan, Yang, Weixian, Guo, Chao, Luo, Xiaoliang, Duan, Xin, Liu, Shengwen, Liu, Rong, Cui, Jingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968174/
https://www.ncbi.nlm.nih.gov/pubmed/36835882
http://dx.doi.org/10.3390/jcm12041347
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author Xu, Haobo
Wang, Juan
Qiao, Shubin
Yuan, Jiansong
Hu, Fenghuan
Yang, Weixian
Guo, Chao
Luo, Xiaoliang
Duan, Xin
Liu, Shengwen
Liu, Rong
Cui, Jingang
author_facet Xu, Haobo
Wang, Juan
Qiao, Shubin
Yuan, Jiansong
Hu, Fenghuan
Yang, Weixian
Guo, Chao
Luo, Xiaoliang
Duan, Xin
Liu, Shengwen
Liu, Rong
Cui, Jingang
author_sort Xu, Haobo
collection PubMed
description Background: Data regarding the association between sleep apnea (SA) and atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) are still limited. We aim to investigate the association of both types of SA, obstructive sleep apnea (OSA) and central sleep apnea (CSA), and nocturnal hypoxemia with AF in HCM. Methods: A total of 606 patients with HCM who underwent sleep evaluations were included. Logistic regression was used to assess the association between sleep disorder and AF. Results: SA was presented in 363 (59.9%) patients, of whom 337 (55.6%) had OSA and 26 (4.3%) had CSA. Patients with SA were older, more often male, had a higher body mass index, and more clinical comorbidities. Prevalence of AF was higher in patients with CSA than patients with OSA and without SA (50.0% versus 24.9% and 12.8%, p < 0.001). After adjustment for age, sex, body mass index, hypertension, diabetes mellitus, cigarette use, New York Heart Association class and severity of mitral regurgitation, SA (OR, 1.79; 95% CI, 1.09–2.94) and nocturnal hypoxemia (higher tertile of percentage of total sleep time with oxygen saturation < 90% [OR, 1.81; 95% CI, 1.05–3.12] compared with lower tertile) were significantly associated with AF. The association was much stronger in the CSA group (OR, 3.98; 95% CI, 1.56–10.13) than in OSA group (OR, 1.66; 95% CI, 1.01–2.76). Similar associations were observed when analyses were restricted to persistent/permanent AF. Conclusion: Both types of SA and nocturnal hypoxemia were independently associated with AF. Attention should be paid to the screening of both types of SA in the management of AF in HCM.
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spelling pubmed-99681742023-02-27 Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy Xu, Haobo Wang, Juan Qiao, Shubin Yuan, Jiansong Hu, Fenghuan Yang, Weixian Guo, Chao Luo, Xiaoliang Duan, Xin Liu, Shengwen Liu, Rong Cui, Jingang J Clin Med Article Background: Data regarding the association between sleep apnea (SA) and atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) are still limited. We aim to investigate the association of both types of SA, obstructive sleep apnea (OSA) and central sleep apnea (CSA), and nocturnal hypoxemia with AF in HCM. Methods: A total of 606 patients with HCM who underwent sleep evaluations were included. Logistic regression was used to assess the association between sleep disorder and AF. Results: SA was presented in 363 (59.9%) patients, of whom 337 (55.6%) had OSA and 26 (4.3%) had CSA. Patients with SA were older, more often male, had a higher body mass index, and more clinical comorbidities. Prevalence of AF was higher in patients with CSA than patients with OSA and without SA (50.0% versus 24.9% and 12.8%, p < 0.001). After adjustment for age, sex, body mass index, hypertension, diabetes mellitus, cigarette use, New York Heart Association class and severity of mitral regurgitation, SA (OR, 1.79; 95% CI, 1.09–2.94) and nocturnal hypoxemia (higher tertile of percentage of total sleep time with oxygen saturation < 90% [OR, 1.81; 95% CI, 1.05–3.12] compared with lower tertile) were significantly associated with AF. The association was much stronger in the CSA group (OR, 3.98; 95% CI, 1.56–10.13) than in OSA group (OR, 1.66; 95% CI, 1.01–2.76). Similar associations were observed when analyses were restricted to persistent/permanent AF. Conclusion: Both types of SA and nocturnal hypoxemia were independently associated with AF. Attention should be paid to the screening of both types of SA in the management of AF in HCM. MDPI 2023-02-08 /pmc/articles/PMC9968174/ /pubmed/36835882 http://dx.doi.org/10.3390/jcm12041347 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Haobo
Wang, Juan
Qiao, Shubin
Yuan, Jiansong
Hu, Fenghuan
Yang, Weixian
Guo, Chao
Luo, Xiaoliang
Duan, Xin
Liu, Shengwen
Liu, Rong
Cui, Jingang
Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
title Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
title_full Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
title_fullStr Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
title_full_unstemmed Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
title_short Association of Types of Sleep Apnea and Nocturnal Hypoxemia with Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
title_sort association of types of sleep apnea and nocturnal hypoxemia with atrial fibrillation in patients with hypertrophic cardiomyopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968174/
https://www.ncbi.nlm.nih.gov/pubmed/36835882
http://dx.doi.org/10.3390/jcm12041347
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