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Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea

Background and Objectives: Determination of the impact of obstructive sleep apnea (OSA) on the cognitive function (CF), and serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and 1β levels and the effect of OSA management on these variables in children. Materials and Methods: A total of 224 p...

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Autores principales: Eldin, Mohamed Shams, Alahmer, Mohamed, Alkashlan, Ebrahim, Zahran, Mahmoud, Eltonsy, Mohamed, Zewail, Amr, Kasem, Abdelfattah, Abdelaal, Khaled, Seddeek, Mahrous, Ahmed, Zakaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968190/
https://www.ncbi.nlm.nih.gov/pubmed/36837406
http://dx.doi.org/10.3390/medicina59020204
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author Eldin, Mohamed Shams
Alahmer, Mohamed
Alkashlan, Ebrahim
Zahran, Mahmoud
Eltonsy, Mohamed
Zewail, Amr
Kasem, Abdelfattah
Abdelaal, Khaled
Seddeek, Mahrous
Ahmed, Zakaria
author_facet Eldin, Mohamed Shams
Alahmer, Mohamed
Alkashlan, Ebrahim
Zahran, Mahmoud
Eltonsy, Mohamed
Zewail, Amr
Kasem, Abdelfattah
Abdelaal, Khaled
Seddeek, Mahrous
Ahmed, Zakaria
author_sort Eldin, Mohamed Shams
collection PubMed
description Background and Objectives: Determination of the impact of obstructive sleep apnea (OSA) on the cognitive function (CF), and serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and 1β levels and the effect of OSA management on these variables in children. Materials and Methods: A total of 224 patients were evaluated using the Pediatric Sleep Questionnaire, the NEPSY score for CF, and polysomnography (PSG) to grade OSA severity according to the apnea/hypopnea index (AHI). Adentonsillectomy (AT) was performed for patients with adenotonsillar hypertrophy grade > 2. Patients with overweight or obesity with mild or moderate OSAS underwent a 6-month protocol of lifestyle intervention (LSI). Blood samples were obtained for an enzyme-linked immunosorbent assay (ELISA) estimation of cytokine levels. All variables were re-evaluated at the end of the 6-month follow-up period. Results: A total of 181 patients had surgical interference and 43 patients underwent a LSI trial; 15 patients failed to respond and underwent surgery. At the end of the follow-up, 33 patients had residual OSAS with a significantly higher incidence among patients with severe OSAS, the mean score of the pediatric sleep questionnaire was significantly decreased in all patients, 181 patients showed an improved NESPY score, and cytokine levels were decreased. The baseline NESPY score, AHI index and sleep questionnaire score were negatively correlated. The percentage of change in the NESPY score and serum cytokine levels showed a positive correlation. Conclusions: OSAS is associated with cognitive dysfunction that significantly improves after adenotonsillectomy. LSI as a therapeutic line is satisfactory for children with mild OSAS and minimal cognitive dysfunction and is of value preoperatively to improve the surgical outcomes of AT.
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spelling pubmed-99681902023-02-27 Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea Eldin, Mohamed Shams Alahmer, Mohamed Alkashlan, Ebrahim Zahran, Mahmoud Eltonsy, Mohamed Zewail, Amr Kasem, Abdelfattah Abdelaal, Khaled Seddeek, Mahrous Ahmed, Zakaria Medicina (Kaunas) Article Background and Objectives: Determination of the impact of obstructive sleep apnea (OSA) on the cognitive function (CF), and serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and 1β levels and the effect of OSA management on these variables in children. Materials and Methods: A total of 224 patients were evaluated using the Pediatric Sleep Questionnaire, the NEPSY score for CF, and polysomnography (PSG) to grade OSA severity according to the apnea/hypopnea index (AHI). Adentonsillectomy (AT) was performed for patients with adenotonsillar hypertrophy grade > 2. Patients with overweight or obesity with mild or moderate OSAS underwent a 6-month protocol of lifestyle intervention (LSI). Blood samples were obtained for an enzyme-linked immunosorbent assay (ELISA) estimation of cytokine levels. All variables were re-evaluated at the end of the 6-month follow-up period. Results: A total of 181 patients had surgical interference and 43 patients underwent a LSI trial; 15 patients failed to respond and underwent surgery. At the end of the follow-up, 33 patients had residual OSAS with a significantly higher incidence among patients with severe OSAS, the mean score of the pediatric sleep questionnaire was significantly decreased in all patients, 181 patients showed an improved NESPY score, and cytokine levels were decreased. The baseline NESPY score, AHI index and sleep questionnaire score were negatively correlated. The percentage of change in the NESPY score and serum cytokine levels showed a positive correlation. Conclusions: OSAS is associated with cognitive dysfunction that significantly improves after adenotonsillectomy. LSI as a therapeutic line is satisfactory for children with mild OSAS and minimal cognitive dysfunction and is of value preoperatively to improve the surgical outcomes of AT. MDPI 2023-01-19 /pmc/articles/PMC9968190/ /pubmed/36837406 http://dx.doi.org/10.3390/medicina59020204 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eldin, Mohamed Shams
Alahmer, Mohamed
Alkashlan, Ebrahim
Zahran, Mahmoud
Eltonsy, Mohamed
Zewail, Amr
Kasem, Abdelfattah
Abdelaal, Khaled
Seddeek, Mahrous
Ahmed, Zakaria
Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea
title Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea
title_full Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea
title_fullStr Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea
title_full_unstemmed Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea
title_short Alterations in Inflammatory Markers and Cognitive Ability after Treatment of Pediatric Obstructive Sleep Apnea
title_sort alterations in inflammatory markers and cognitive ability after treatment of pediatric obstructive sleep apnea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968190/
https://www.ncbi.nlm.nih.gov/pubmed/36837406
http://dx.doi.org/10.3390/medicina59020204
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