Cargando…

Synthesis, Characterization, and Biological Evaluation of Meldrum’s Acid Derivatives: Dual Activity and Molecular Docking Study

In the presented study, eight novel Meldrum’s acid derivatives containing various vanillic groups were synthesized. Vanillidene Meldrum’s acid compounds were tested against different cancer cell lines and microbes. Out of nine, three showed very good biological activity against E. coli, and HeLa and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bukhari, Syed Nasir Abbas, Abdelgawad, Mohamed Abdelwahab, Ahmed, Naveed, Amjad, Muhammad Wahab, Hussain, Muhammad Ajaz, Elsherif, Mervat A., Ejaz, Hasan, Alotaibi, Nasser H., Filipović, Ignjat, Janković, Nenad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968196/ https://www.ncbi.nlm.nih.gov/pubmed/37259425 http://dx.doi.org/10.3390/ph16020281

Ejemplares similares

Covalent Organic Frameworks (COFs) as Multi-Target Multifunctional Frameworks
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2023)

Extraction Optimization of Mucilage from Seeds of Mimosa pudica by Response Surface Methodology
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Dual activity of indolin-2-ones containing an arylidene motif: DNA and BSA interaction
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2023)

Metal Complexation of Arabinoxylan Engenders a Smart Material Offering pH, Solvents, and Salt Responsive On–Off Swelling with the Potential for Sustained Drug Delivery
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Antihypertensive and Vasorelaxant Effects of Citrus aurantifolia Linn. Fruit: Proposed Mechanisms
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Protective Effect of Butanolic Fraction of Delphinium brunonianum on Fructose-Mediated Metabolic Alterations in Rats
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

The Meldrum Forced-Draught Furnace
Publicado: (1921)

Design and Synthesis of Some New Furan-Based Derivatives and Evaluation of In Vitro Cytotoxic Activity
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Co-Combination of Pregabalin and Withania coagulans-Extract-Loaded Topical Gel Alleviates Allodynia and Hyperalgesia in the Chronic Sciatic Nerve Constriction Injury for Neuropathic Pain in Animal Model
por: Asghar, Anam, et al.
Publicado: (2022)

The Reactions of N,N′-Diphenyldithiomalondiamide with Arylmethylidene Meldrum’s Acids
por: Dotsenko, Victor V., et al.
Publicado: (2022)

Perceiving the Concealed and Unreported Pharmacophoric Features of the 5-Hydroxytryptamine Receptor Using Balanced QSAR Analysis
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Withania somnifera L.: Insights into the phytochemical profile, therapeutic potential, clinical trials, and future prospective
por: Saleem, Sumaira, et al.
Publicado: (2020)

Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach
por: Avula, Satya Kumar, et al.
Publicado: (2023)

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation
por: Noreen, Sobia, et al.
Publicado: (2022)

Preparation, Characterization of Pregabalin and Withania coagulans Extract-Loaded Topical Gel and Their Comparative Effect on Burn Injury
por: Asghar, Anam, et al.
Publicado: (2022)

Polymerization of Meldrum’s Acid and Diisocyanate: An Effective Approach for Preparation of Reactive Polyamides and Polyurethanes
por: Chen, Ying-Chen, et al.
Publicado: (2019)

Design, Synthesis, In Vitro Biological Activity Evaluation and Stabilized Nanostructured Lipid Carrier Formulation of Newly Synthesized Schiff Bases-Based TMP Moieties
por: Bukhari, Syed Nasir Abbas, et al.
Publicado: (2022)

Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability
por: Hussain, Muhammad Ajaz, et al.
Publicado: (2020)

An Evaluation of the Binding Strength of Okra Gum and the Drug Release Characteristics of Tablets Prepared from It
por: Hussain, Amjad, et al.
Publicado: (2017)

Three-Component Synthesis of Pyridylacetic Acid Derivatives by Arylation/Decarboxylative Substitution of Meldrum’s Acids
por: Johnson, Tarn C., et al.
Publicado: (2022)

Innovative Bio-Based Organic UV-A and Blue Light Filters from Meldrum’s Acid
por: Peyrot, Cédric, et al.
Publicado: (2020)

One pot light assisted green synthesis, storage and antimicrobial activity of dextran stabilized silver nanoparticles
por: Hussain, Muhammad Ajaz, et al.
Publicado: (2014)

Hydroxypropylcellulose as a novel green reservoir for the synthesis, stabilization, and storage of silver nanoparticles
por: Hussain, Muhammad Ajaz, et al.
Publicado: (2015)

Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications
por: Haseeb, Muhammad Tahir, et al.
Publicado: (2017)

Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation
por: Noureen, Shazia, et al.
Publicado: (2022)

Meldrum’s Acid Furfural Conjugate MAFC: A New Entry as Chromogenic Sensor for Specific Amine Identification
por: Zeußel, Lisa, et al.
Publicado: (2023)

Antibiogram and recent incidence of multi-drug resistant carbapenemase producing Escherichia coli isolated from paediatric patients
por: Nosheen, Sumbal, et al.
Publicado: (2020)

Kinetic Spectrophotometric Method for the 1,4-Diionic Organophosphorus Formation in the Presence of Meldrum′s Acid: Stopped-Flow Approach
por: Ghodsi, Fatemeh, et al.
Publicado: (2016)

Effective Synthesis Route for Linear and Cross-Linked Biodegradable Polyesters Using Aliphatic Meldrum’s Acid Derivatives as Monomers
por: Lin, Liang-Kai, et al.
Publicado: (2018)

Synthesis, Crystal Structures, and Density Functional Theory Studies of Two Salt Cocrystals Containing Meldrum’s Acid Group
por: Zeng, Wulan, et al.
Publicado: (2022)

Synthesis of pH-Sensitive Cross-Linked Basil Seed Gum/Acrylic Acid Hydrogels by Free Radical Copolymerization Technique for Sustained Delivery of Captopril
por: Ghumman, Shazia Akram, et al.
Publicado: (2022)

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
por: Rashid, Memoona, et al.
Publicado: (2020)

A stimuli-responsive, superporous and non-toxic smart hydrogel from seeds of mugwort (Artemisia vulgaris): stimuli responsive swelling/deswelling, intelligent drug delivery and enhanced aceclofenac bioavailability
por: Farid-ul-Haq, Muhammad, et al.
Publicado: (2020)

Appraisal of the Antiarthritic Potential of Prazosin via Inhibition of Proinflammatory Cytokine TNF-α: A Key Player in Rheumatoid Arthritis
por: Qasim, Sumera, et al.
Publicado: (2021)

Polysaccharide-Based Hydrogel from Seeds of Artemisia vulgaris: Extraction Optimization by Box–Behnken Design, pH-Responsiveness, and Sustained Drug Release
por: Hussain, Muhammad Ajaz, et al.
Publicado: (2023)

Synthesis and Characterization of Antibiotic–Loaded Biodegradable Citrate Functionalized Mesoporous Hydroxyapatite Nanocarriers as an Alternative Treatment for Bone Infections
por: Alotaibi, Nasser H., et al.
Publicado: (2022)

Crystal Structure, Photophysical Study, Hirshfeld Surface Analysis, and Nonlinear Optical Properties of a New Hydroxyphenylamino Meldrum’s Acid Derivative
por: Zeng, Wulan, et al.
Publicado: (2023)

Pharmaceutical and Pharmacological Evaluation of Amoxicillin after Solubility Enhancement Using the Spray Drying Technique
por: Hassan, Faiza, et al.
Publicado: (2022)

Multiple Antimicrobial Resistance and Heavy Metal Tolerance of Biofilm-Producing Bacteria Isolated from Dairy and Non-Dairy Food Products
por: Ejaz, Hasan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5o9cs8pq20hf0m1v1hu99voddb