Cargando…

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Brown adipose tissue (BAT) plays a pivotal role in maintaining body temperature and energy homeostasis. BAT dysfunction is associated with impaired metabolic health. Here, we show that Ssu72 phosphatase is essential for mRNA translation of genes required for thermogenesis in BAT. Ssu72 is found to b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Eun-Ji, Kim, Hyun-Soo, Lee, Do-Hyoung, Kim, Su-Min, Yoon, Joon-Sup, Lee, Ji-Min, Im, Se Jin, Lee, Ho, Lee, Min-Woo, Lee, Chang-Woo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968297/ https://www.ncbi.nlm.nih.gov/pubmed/36841836 http://dx.doi.org/10.1038/s41467-023-36836-y

Ejemplares similares

Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4(+) T Cell Lineages
por: Kim, Min-Hee, et al.
Publicado: (2023)

Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases
por: Hwang, Soeun, et al.
Publicado: (2021)

Mammalian Ssu72 phosphatase preferentially considers tissue-specific actively transcribed gene expression by regulating RNA Pol II transcription
por: Kim, Hyun-Soo, et al.
Publicado: (2022)

Ssu72 phosphatase is a conserved telomere replication terminator
por: Escandell, Jose Miguel, et al.
Publicado: (2019)

Ssu72 attenuates autoimmune arthritis via targeting of STAT3 signaling and Th17 activation
por: Lee, Seung Hoon, et al.
Publicado: (2017)

Conserved and specific functions of mammalian ssu72
por: St-Pierre, Benoit, et al.
Publicado: (2005)

A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation
por: Chen, Yupeng, et al.
Publicado: (2014)

Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex
por: Xiang, Kehui, et al.
Publicado: (2010)

Functional interaction of human Ssu72 with RNA polymerase II complexes
por: Spector, Benjamin M., et al.
Publicado: (2019)

Ssu72 Regulates Fungal Development, Aflatoxin Biosynthesis and Pathogenicity in Aspergillus flavus
por: Yang, Guang, et al.
Publicado: (2020)

Protein phosphatases regulate the liver microenvironment in the development of hepatocellular carcinoma
por: Yoon, Joon-Sup, et al.
Publicado: (2022)

Dimerization of Translationally Controlled Tumor Protein Is Essential For Its Cytokine-Like Activity
por: Kim, Miyoung, et al.
Publicado: (2009)

Influence of Overcrowding in the Emergency Department on Return Visit within 72 H
por: Kim, Dong-uk, et al.
Publicado: (2020)

Vertebrate Ssu72 Regulates and Coordinates 3′-End Formation of RNAs Transcribed by RNA Polymerase II
por: Wani, Shotaro, et al.
Publicado: (2014)

Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72
por: Zhao, Yan, et al.
Publicado: (2022)

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice
por: Park, Anna, et al.
Publicado: (2023)

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling
por: Lee, Yuna, et al.
Publicado: (2022)

The Essential Function of miR-5739 in Embryonic Muscle Development
por: Lee, Ji-Heon, et al.
Publicado: (2023)

Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
por: Song, No-Joon, et al.
Publicado: (2017)

Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3′ processing and transcription termination that functions via its effects on CTD phosphatase Ssu72
por: Sanchez, Ana M, et al.
Publicado: (2020)

The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription
por: Wang, Yi-Ting, et al.
Publicado: (2021)

Thermogenic crosstalk occurs between adipocytes from different species
por: Gilor, Chen, et al.
Publicado: (2019)

ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD
por: Park, Jumin, et al.
Publicado: (2021)

Anti-Obesity Effects of Grateloupia elliptica, a Red Seaweed, in Mice with High-Fat Diet-Induced Obesity via Suppression of Adipogenic Factors in White Adipose Tissue and Increased Thermogenic Factors in Brown Adipose Tissue
por: Lee, Hyo-Geun, et al.
Publicado: (2020)

The thermogenic characteristics of adipocytes are dependent on the regulation of iron homeostasis
por: Yook, Jin-Seon, et al.
Publicado: (2021)

Anti-Obesity Effects of Sargassum thunbergii via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice
por: Kang, Min-Cheol, et al.
Publicado: (2020)

Anterior Optic Nerve Head Perfusion is Dependent on Adjacent Parapapillary Choroidal perfusion
por: Lee, Kyoung Min, et al.
Publicado: (2019)

Difference in topographic morphology of optic nerve head and neuroretinal rim between normal tension glaucoma and central retinal artery occlusion
por: Kim, Ji-Ah, et al.
Publicado: (2022)

Clinical Features of Benign Essential Blepharospasm in Korean Patients
por: Lee, Jeong Min, et al.
Publicado: (2018)

Survivin is essential for thermogenic program and metabolic homeostasis in mice
por: Alimujiang, Miriayi, et al.
Publicado: (2022)

Translation and validation of the patient-Generated Subjective Global Assessment against the Mini-Nutritional Assessment for patients with gastric cancer
por: Lee, Ji Yea, et al.
Publicado: (2022)

MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
por: Ding, Chien-Kuang Cornelia, et al.
Publicado: (2020)

Molecular Epidemiology of Respiratory Syncytial Virus A G-Protein for 9 Years and Emergence of ON1 Genotype Having 72 Nucleotide Duplication in Korea
por: Yun, Ki Wook, et al.
Publicado: (2017)

Cytosolic microRNA-inducible nuclear translocation of Cas9 protein for disease-specific genome modification
por: Shin, Cheol-Hee, et al.
Publicado: (2022)

The thermogenic circuit: Regulators of thermogenic competency and differentiation
por: Lynes, Matthew D., et al.
Publicado: (2015)

Development of CIDEA reporter mouse model and its application for screening thermogenic drugs
por: Son, Yeonho, et al.
Publicado: (2021)

Thermogenic adipose tissue in energy regulation and metabolic health
por: Xue, Siwen, et al.
Publicado: (2023)

Hypothalamic administration of sargahydroquinoic acid elevates peripheral thermogenic signaling and ameliorates high fat diet-induced obesity through the sympathetic nervous system
por: Kim, Doyeon, et al.
Publicado: (2021)

Real-World Effectiveness, Treatment Pattern, and Safety of Ranibizumab in Korean Patients with Neovascular Age-Related Macular Degeneration: Subgroup Analyses from the LUMINOUS Study
por: Sagong, Min, et al.
Publicado: (2021)

Immune Cells in Thermogenic Adipose Depots: The Essential but Complex Relationship
por: Agueda-Oyarzabal, Marina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_90fjinmh7flkqnf69hva57vp70