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Physicochemical and nanomedicine applications of phyto-reduced erbium oxide (Er(2)O(3)) nanoparticles
Hyphaene thebaica fruits were used for the fabrication of spherical erbium oxide nanoparticles (HT-Er(2)O(3) NP(S)) using a one-step simple bioreduction process. XRD pattern revealed a highly crystalline and pure phase with crystallite size of ~ 7.5 nm, whereas, the W–H plot revealed crystallite siz...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968365/ https://www.ncbi.nlm.nih.gov/pubmed/36840788 http://dx.doi.org/10.1186/s13568-023-01527-w |
Sumario: | Hyphaene thebaica fruits were used for the fabrication of spherical erbium oxide nanoparticles (HT-Er(2)O(3) NP(S)) using a one-step simple bioreduction process. XRD pattern revealed a highly crystalline and pure phase with crystallite size of ~ 7.5 nm, whereas, the W–H plot revealed crystallite size of 11 nm. FTIR spectra revealed characteristic Er-O atomic vibrations in the fingerprint region. Bandgap was obtained as 5.25 eV using K-M function. The physicochemical and morphological nature was established using Raman spectroscopy, reflectance spectroscopy, SAED and HR-TEM. HT-Er(2)O(3) NP(S) were further evaluated for antidiabetic potential in mice using in-vivo and in-vitro bioassays. The synthesized HT-Er(2)O(3) NP(S) were screened for in vitro anti-diabetic potentials against α-glucosidase enzyme and α-amylase enzyme and their antioxidant potential was evaluated using DPPH free radical assay. A dose dependent inhibition was obtained against α-glucosidase (IC(50) 12 μg/mL) and α-amylase (IC(50) 78 μg/mL) while good DPPH free radical scavenging potential (IC(50) 78 μg mL(−1)) is reported. At 1000 μg/mL, the HT-Er(2)O(3) NP(S) revealed 90.30% and 92.30% inhibition of α-amylase and α-glucosidase enzymes. HT-Er(2)O(3) NPs treated groups were observed to have better glycemic control in diabetic animals (503.66 ± 5.92*** on day 0 and 185.66 ± 2.60*** on day 21) when compared with positive control glibenclamide treated group. Further, HT-Er(2)O(3) NP(S) therapy for 21 days caused a considerable effect on serum total lipids, cholesterol, triglycerides, HDL and LDL as compared to untreated diabetic group. In conclusion, our preliminary findings on HT-Er(2)O(3) NP(S) revealed considerable antidiabetic potential and thus can be an effective candidate for controlling the post-prandial hyperglycemia. However, further studies are encouraged especially taking into consideration the toxicity aspects of the nanomaterial. |
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