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Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes

BACKGROUND: COVID-19 has led to an unprecedented global health crisis. This situation caused an immediate reduction in solid organ transplantation activity. This study aimed to present the follow-up results of patients with chronic liver disease who underwent liver transplantation (LT) after a histo...

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Autores principales: Akbulut, Sami, Barut, Bora, Garzali, Ibrahim Umar, Sarici, Kemal Baris, Tamer, Murat, Unsal, Selver, Karabulut, Ertugrul, Baskiran, Adil, Bayindir, Yasar, Yilmaz, Sezai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968604/
https://www.ncbi.nlm.nih.gov/pubmed/36973149
http://dx.doi.org/10.1016/j.transproceed.2023.01.024
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author Akbulut, Sami
Barut, Bora
Garzali, Ibrahim Umar
Sarici, Kemal Baris
Tamer, Murat
Unsal, Selver
Karabulut, Ertugrul
Baskiran, Adil
Bayindir, Yasar
Yilmaz, Sezai
author_facet Akbulut, Sami
Barut, Bora
Garzali, Ibrahim Umar
Sarici, Kemal Baris
Tamer, Murat
Unsal, Selver
Karabulut, Ertugrul
Baskiran, Adil
Bayindir, Yasar
Yilmaz, Sezai
author_sort Akbulut, Sami
collection PubMed
description BACKGROUND: COVID-19 has led to an unprecedented global health crisis. This situation caused an immediate reduction in solid organ transplantation activity. This study aimed to present the follow-up results of patients with chronic liver disease who underwent liver transplantation (LT) after a history of COVID-19 infection. METHODS: Sociodemographic characteristics and clinicopathological data of 474 patients who underwent LT at Inonu University Liver Transplant Institute between March 11, 2020 and March 17, 2022 were prospectively recorded and analyzed retrospectively. Among these, the data of 35 patients with chronic liver disease who were found to be exposed to COVID-19 infection in the pre-LT period were analyzed for this study. RESULTS: The median body mass index, Child score, and Model for end-stage liver disease/ Pediatric end-stage liver disease scores of the 35 patients were calculated as 25.1 kg/m(2) (IQR: 7.4), 9 points (IQR: 4), and 16 points (IQR: 10), respectively. Graft rejection occurred in 4 patients at a median of 25 days post-transplant. Five patients underwent retransplantation at a median of 25 days post-transplant. The most common cause of retransplantation is early hepatic artery thrombosis. There were 5 deaths during postoperative follow-up. Mortality developed in 5 (14.3%) patients exposed to COVID-19 infection in the pretransplant period, whereas mortality occurred in 56 (12.8%) patients not exposed to COVID-19 infection. There was no statistically significant difference in mortality between the groups (P = .79). CONCLUSIONS: The results of this study showed that exposure to COVID-19 before LT does not affect post-transplant patients and graft survival.
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spelling pubmed-99686042023-02-27 Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes Akbulut, Sami Barut, Bora Garzali, Ibrahim Umar Sarici, Kemal Baris Tamer, Murat Unsal, Selver Karabulut, Ertugrul Baskiran, Adil Bayindir, Yasar Yilmaz, Sezai Transplant Proc Article BACKGROUND: COVID-19 has led to an unprecedented global health crisis. This situation caused an immediate reduction in solid organ transplantation activity. This study aimed to present the follow-up results of patients with chronic liver disease who underwent liver transplantation (LT) after a history of COVID-19 infection. METHODS: Sociodemographic characteristics and clinicopathological data of 474 patients who underwent LT at Inonu University Liver Transplant Institute between March 11, 2020 and March 17, 2022 were prospectively recorded and analyzed retrospectively. Among these, the data of 35 patients with chronic liver disease who were found to be exposed to COVID-19 infection in the pre-LT period were analyzed for this study. RESULTS: The median body mass index, Child score, and Model for end-stage liver disease/ Pediatric end-stage liver disease scores of the 35 patients were calculated as 25.1 kg/m(2) (IQR: 7.4), 9 points (IQR: 4), and 16 points (IQR: 10), respectively. Graft rejection occurred in 4 patients at a median of 25 days post-transplant. Five patients underwent retransplantation at a median of 25 days post-transplant. The most common cause of retransplantation is early hepatic artery thrombosis. There were 5 deaths during postoperative follow-up. Mortality developed in 5 (14.3%) patients exposed to COVID-19 infection in the pretransplant period, whereas mortality occurred in 56 (12.8%) patients not exposed to COVID-19 infection. There was no statistically significant difference in mortality between the groups (P = .79). CONCLUSIONS: The results of this study showed that exposure to COVID-19 before LT does not affect post-transplant patients and graft survival. Elsevier Inc. 2023-06 2023-02-27 /pmc/articles/PMC9968604/ /pubmed/36973149 http://dx.doi.org/10.1016/j.transproceed.2023.01.024 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Akbulut, Sami
Barut, Bora
Garzali, Ibrahim Umar
Sarici, Kemal Baris
Tamer, Murat
Unsal, Selver
Karabulut, Ertugrul
Baskiran, Adil
Bayindir, Yasar
Yilmaz, Sezai
Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes
title Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes
title_full Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes
title_fullStr Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes
title_full_unstemmed Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes
title_short Effect of Pre-Transplant Covid-19 Exposure on Post-Liver Transplant Clinical Outcomes
title_sort effect of pre-transplant covid-19 exposure on post-liver transplant clinical outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968604/
https://www.ncbi.nlm.nih.gov/pubmed/36973149
http://dx.doi.org/10.1016/j.transproceed.2023.01.024
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