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Insight into the mechanisms of coronaviruses evading host innate immunity

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic disease to full-blown pneumonia and multiorgan fa...

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Autores principales: Yao, Tengteng, Foo, Chingchoon, Zheng, Guopei, Huang, Rui, Li, Qian, Shen, Jianfeng, Wang, Zhaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968664/
https://www.ncbi.nlm.nih.gov/pubmed/36858323
http://dx.doi.org/10.1016/j.bbadis.2023.166671
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author Yao, Tengteng
Foo, Chingchoon
Zheng, Guopei
Huang, Rui
Li, Qian
Shen, Jianfeng
Wang, Zhaoyang
author_facet Yao, Tengteng
Foo, Chingchoon
Zheng, Guopei
Huang, Rui
Li, Qian
Shen, Jianfeng
Wang, Zhaoyang
author_sort Yao, Tengteng
collection PubMed
description The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic disease to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production of interferons (IFNs) in the severe cases were significantly lower than their milder counterparts, suggesting linkage of COVID-19 to impaired innate immunity. This review presents a brief overview of how coronaviruses evade innate immunity, according to the current studies about SARS-CoV and middle-east respiratory syndrome-coronavirus (MERS-CoV). The coronaviruses manage to block, escape, or dampen the innate immune response by antagonizing double-stranded RNA (dsRNA) sensor, mitochondrial antiviral-signaling protein (MAVS) and stimulator of IFN genes (STING) pathways, epigenetic modification, posttranslational modifications, and host mRNA translation. We provide novel insights into a comprehensive therapy to combat SARS-CoV-2 infection.
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spelling pubmed-99686642023-02-27 Insight into the mechanisms of coronaviruses evading host innate immunity Yao, Tengteng Foo, Chingchoon Zheng, Guopei Huang, Rui Li, Qian Shen, Jianfeng Wang, Zhaoyang Biochim Biophys Acta Mol Basis Dis Article The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic disease to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production of interferons (IFNs) in the severe cases were significantly lower than their milder counterparts, suggesting linkage of COVID-19 to impaired innate immunity. This review presents a brief overview of how coronaviruses evade innate immunity, according to the current studies about SARS-CoV and middle-east respiratory syndrome-coronavirus (MERS-CoV). The coronaviruses manage to block, escape, or dampen the innate immune response by antagonizing double-stranded RNA (dsRNA) sensor, mitochondrial antiviral-signaling protein (MAVS) and stimulator of IFN genes (STING) pathways, epigenetic modification, posttranslational modifications, and host mRNA translation. We provide novel insights into a comprehensive therapy to combat SARS-CoV-2 infection. Elsevier B.V. 2023-06 2023-02-27 /pmc/articles/PMC9968664/ /pubmed/36858323 http://dx.doi.org/10.1016/j.bbadis.2023.166671 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Yao, Tengteng
Foo, Chingchoon
Zheng, Guopei
Huang, Rui
Li, Qian
Shen, Jianfeng
Wang, Zhaoyang
Insight into the mechanisms of coronaviruses evading host innate immunity
title Insight into the mechanisms of coronaviruses evading host innate immunity
title_full Insight into the mechanisms of coronaviruses evading host innate immunity
title_fullStr Insight into the mechanisms of coronaviruses evading host innate immunity
title_full_unstemmed Insight into the mechanisms of coronaviruses evading host innate immunity
title_short Insight into the mechanisms of coronaviruses evading host innate immunity
title_sort insight into the mechanisms of coronaviruses evading host innate immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968664/
https://www.ncbi.nlm.nih.gov/pubmed/36858323
http://dx.doi.org/10.1016/j.bbadis.2023.166671
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