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Insight into the mechanisms of coronaviruses evading host innate immunity
The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic disease to full-blown pneumonia and multiorgan fa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968664/ https://www.ncbi.nlm.nih.gov/pubmed/36858323 http://dx.doi.org/10.1016/j.bbadis.2023.166671 |
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author | Yao, Tengteng Foo, Chingchoon Zheng, Guopei Huang, Rui Li, Qian Shen, Jianfeng Wang, Zhaoyang |
author_facet | Yao, Tengteng Foo, Chingchoon Zheng, Guopei Huang, Rui Li, Qian Shen, Jianfeng Wang, Zhaoyang |
author_sort | Yao, Tengteng |
collection | PubMed |
description | The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic disease to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production of interferons (IFNs) in the severe cases were significantly lower than their milder counterparts, suggesting linkage of COVID-19 to impaired innate immunity. This review presents a brief overview of how coronaviruses evade innate immunity, according to the current studies about SARS-CoV and middle-east respiratory syndrome-coronavirus (MERS-CoV). The coronaviruses manage to block, escape, or dampen the innate immune response by antagonizing double-stranded RNA (dsRNA) sensor, mitochondrial antiviral-signaling protein (MAVS) and stimulator of IFN genes (STING) pathways, epigenetic modification, posttranslational modifications, and host mRNA translation. We provide novel insights into a comprehensive therapy to combat SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-9968664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99686642023-02-27 Insight into the mechanisms of coronaviruses evading host innate immunity Yao, Tengteng Foo, Chingchoon Zheng, Guopei Huang, Rui Li, Qian Shen, Jianfeng Wang, Zhaoyang Biochim Biophys Acta Mol Basis Dis Article The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) has recently caused a pandemic. Patients with COVID-19 presented with a wide spectrum of symptoms for the disease, from entirely asymptomatic disease to full-blown pneumonia and multiorgan failures. More evidence emerged, showing the production of interferons (IFNs) in the severe cases were significantly lower than their milder counterparts, suggesting linkage of COVID-19 to impaired innate immunity. This review presents a brief overview of how coronaviruses evade innate immunity, according to the current studies about SARS-CoV and middle-east respiratory syndrome-coronavirus (MERS-CoV). The coronaviruses manage to block, escape, or dampen the innate immune response by antagonizing double-stranded RNA (dsRNA) sensor, mitochondrial antiviral-signaling protein (MAVS) and stimulator of IFN genes (STING) pathways, epigenetic modification, posttranslational modifications, and host mRNA translation. We provide novel insights into a comprehensive therapy to combat SARS-CoV-2 infection. Elsevier B.V. 2023-06 2023-02-27 /pmc/articles/PMC9968664/ /pubmed/36858323 http://dx.doi.org/10.1016/j.bbadis.2023.166671 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Yao, Tengteng Foo, Chingchoon Zheng, Guopei Huang, Rui Li, Qian Shen, Jianfeng Wang, Zhaoyang Insight into the mechanisms of coronaviruses evading host innate immunity |
title | Insight into the mechanisms of coronaviruses evading host innate immunity |
title_full | Insight into the mechanisms of coronaviruses evading host innate immunity |
title_fullStr | Insight into the mechanisms of coronaviruses evading host innate immunity |
title_full_unstemmed | Insight into the mechanisms of coronaviruses evading host innate immunity |
title_short | Insight into the mechanisms of coronaviruses evading host innate immunity |
title_sort | insight into the mechanisms of coronaviruses evading host innate immunity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968664/ https://www.ncbi.nlm.nih.gov/pubmed/36858323 http://dx.doi.org/10.1016/j.bbadis.2023.166671 |
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