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A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip

BACKGROUND: Hip involvement predicts severe disease in juvenile idiopathic arthritis (JIA) and is accurately assessed by MRI. However, a child-specific hip MRI scoring system has not been validated. OBJECTIVE: To test the intra- and interobserver agreement of several MRI markers for active and chron...

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Autores principales: Tanturri de Horatio, Laura, Shelmerdine, Susan C., d’Angelo, Paola, Di Paolo, Pier Luigi, Magni-Manzoni, Silvia, Malattia, Clara, Damasio, Maria Beatrice, Tomà, Paolo, Avenarius, Derk, Rosendahl, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968695/
https://www.ncbi.nlm.nih.gov/pubmed/36149477
http://dx.doi.org/10.1007/s00247-022-05502-8
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author Tanturri de Horatio, Laura
Shelmerdine, Susan C.
d’Angelo, Paola
Di Paolo, Pier Luigi
Magni-Manzoni, Silvia
Malattia, Clara
Damasio, Maria Beatrice
Tomà, Paolo
Avenarius, Derk
Rosendahl, Karen
author_facet Tanturri de Horatio, Laura
Shelmerdine, Susan C.
d’Angelo, Paola
Di Paolo, Pier Luigi
Magni-Manzoni, Silvia
Malattia, Clara
Damasio, Maria Beatrice
Tomà, Paolo
Avenarius, Derk
Rosendahl, Karen
author_sort Tanturri de Horatio, Laura
collection PubMed
description BACKGROUND: Hip involvement predicts severe disease in juvenile idiopathic arthritis (JIA) and is accurately assessed by MRI. However, a child-specific hip MRI scoring system has not been validated. OBJECTIVE: To test the intra- and interobserver agreement of several MRI markers for active and chronic hip changes in children and young adults with JIA and to examine the precision of measurements commonly used for the assessment of growth abnormalities. MATERIALS AND METHODS: Hip MRIs from 60 consecutive children, adolescents and young adults with JIA were scored independently by two sets of radiologists. One set scored the same MRIs twice. Features of active and chronic changes, growth abnormalities and secondary post-inflammatory changes were scored. We used kappa statistics to analyze inter- and intraobserver agreement for categorical variables and a Bland–Altman approach to test the precision of continuous variables. RESULTS: Among active changes, there was good intra- and interobserver agreement for grading overall inflammation (kappa 0.6–0.7). Synovial enhancement showed a good intraobserver agreement (kappa 0.7–0.8), while the interobserver agreement was moderate (kappa 0.4–0.5). Regarding acetabular erosions on a 0–3 scale, the intraobserver agreement was 0.6 for the right hip and 0.7 for the left hip, while the interobserver agreement was 0.6 for both hips. Measurements of joint space width, caput–collum–diaphyseal angle, femoral neck–head length, femoral width and trochanteric distance were imprecise. CONCLUSION: We identified a set of MRI markers for active and chronic changes in JIA and suggest that the more robust markers be included in future studies addressing clinical validity and long-term patient outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00247-022-05502-8.
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spelling pubmed-99686952023-02-28 A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip Tanturri de Horatio, Laura Shelmerdine, Susan C. d’Angelo, Paola Di Paolo, Pier Luigi Magni-Manzoni, Silvia Malattia, Clara Damasio, Maria Beatrice Tomà, Paolo Avenarius, Derk Rosendahl, Karen Pediatr Radiol Original Article BACKGROUND: Hip involvement predicts severe disease in juvenile idiopathic arthritis (JIA) and is accurately assessed by MRI. However, a child-specific hip MRI scoring system has not been validated. OBJECTIVE: To test the intra- and interobserver agreement of several MRI markers for active and chronic hip changes in children and young adults with JIA and to examine the precision of measurements commonly used for the assessment of growth abnormalities. MATERIALS AND METHODS: Hip MRIs from 60 consecutive children, adolescents and young adults with JIA were scored independently by two sets of radiologists. One set scored the same MRIs twice. Features of active and chronic changes, growth abnormalities and secondary post-inflammatory changes were scored. We used kappa statistics to analyze inter- and intraobserver agreement for categorical variables and a Bland–Altman approach to test the precision of continuous variables. RESULTS: Among active changes, there was good intra- and interobserver agreement for grading overall inflammation (kappa 0.6–0.7). Synovial enhancement showed a good intraobserver agreement (kappa 0.7–0.8), while the interobserver agreement was moderate (kappa 0.4–0.5). Regarding acetabular erosions on a 0–3 scale, the intraobserver agreement was 0.6 for the right hip and 0.7 for the left hip, while the interobserver agreement was 0.6 for both hips. Measurements of joint space width, caput–collum–diaphyseal angle, femoral neck–head length, femoral width and trochanteric distance were imprecise. CONCLUSION: We identified a set of MRI markers for active and chronic changes in JIA and suggest that the more robust markers be included in future studies addressing clinical validity and long-term patient outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00247-022-05502-8. Springer Berlin Heidelberg 2022-09-23 2023 /pmc/articles/PMC9968695/ /pubmed/36149477 http://dx.doi.org/10.1007/s00247-022-05502-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Tanturri de Horatio, Laura
Shelmerdine, Susan C.
d’Angelo, Paola
Di Paolo, Pier Luigi
Magni-Manzoni, Silvia
Malattia, Clara
Damasio, Maria Beatrice
Tomà, Paolo
Avenarius, Derk
Rosendahl, Karen
A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
title A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
title_full A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
title_fullStr A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
title_full_unstemmed A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
title_short A novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
title_sort novel magnetic resonance imaging scoring system for active and chronic changes in children and adolescents with juvenile idiopathic arthritis of the hip
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968695/
https://www.ncbi.nlm.nih.gov/pubmed/36149477
http://dx.doi.org/10.1007/s00247-022-05502-8
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