Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line

Amongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the closest to traditional apical endpoints, whilst offering mechanistic insights into the biological perturbations. Despite this, the application of untarg...

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Detalles Bibliográficos
Autores principales: Malinowska, Julia M., Palosaari, Taina, Sund, Jukka, Carpi, Donatella, Weber, Ralf J. M., Lloyd, Gavin R., Whelan, Maurice, Viant, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968698/
https://www.ncbi.nlm.nih.gov/pubmed/36683062
http://dx.doi.org/10.1007/s00204-022-03439-3

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