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Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice

INTRODUCTION: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that typically involve diarrhea, abdominal pain, fatigue, and weight loss, with a dramatic impact on patients’ quality of life. Standard medications are often associated with adverse side effects. Thus, alternative t...

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Autores principales: Manna, Laura, Rizzi, Eleonora, Bafile, Eleonora, Cappelleri, Andrea, Ruscica, Massimiliano, Macchi, Chiara, Podaliri Vulpiani, Michele, Salini, Romolo, Rossi, Emanuela, Panebianco, Concetta, Perri, Francesco, Pazienza, Valerio, Federici, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968723/
https://www.ncbi.nlm.nih.gov/pubmed/36860688
http://dx.doi.org/10.3389/fnut.2023.1072334
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author Manna, Laura
Rizzi, Eleonora
Bafile, Eleonora
Cappelleri, Andrea
Ruscica, Massimiliano
Macchi, Chiara
Podaliri Vulpiani, Michele
Salini, Romolo
Rossi, Emanuela
Panebianco, Concetta
Perri, Francesco
Pazienza, Valerio
Federici, Federica
author_facet Manna, Laura
Rizzi, Eleonora
Bafile, Eleonora
Cappelleri, Andrea
Ruscica, Massimiliano
Macchi, Chiara
Podaliri Vulpiani, Michele
Salini, Romolo
Rossi, Emanuela
Panebianco, Concetta
Perri, Francesco
Pazienza, Valerio
Federici, Federica
author_sort Manna, Laura
collection PubMed
description INTRODUCTION: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that typically involve diarrhea, abdominal pain, fatigue, and weight loss, with a dramatic impact on patients’ quality of life. Standard medications are often associated with adverse side effects. Thus, alternative treatments such as probiotics are of great interest. The purpose of the present study was to evaluate the effects of oral administration of Lentilactobacillus kefiri (basonym: Lactobacillus kefiri) SGL 13 and Andrographis paniculata, namely, Paniculin 13™, on dextran sodium sulfate (DSS)- treated C57BL/6J mice. METHODS: Colitis was induced by administering 1.5% DSS in drinking water for 9 days. Forty male mice were divided into four groups, receiving PBS (control), 1.5% DSS, Paniculin 13™ and 1.5% DSS + Paniculin 13™. RESULTS: The results showed that body weight loss and Disease Activity Index (DAI) score were improved by Paniculin 13™. Moreover, Paniculin 13™ ameliorated DSS-induced dysbiosis, by modulating the gut microbiota composition. The gene expression of MPO, TNFα and iNOS in colon tissue was reduced and these data matched with the histological results, supporting the efficacy of Paniculin 13™ in reducing the inflammatory response. No adverse effects were associated to Paniculin 13™ administration. DISCUSSION: In conclusion, Paniculin 13™ could be an effective add-on approach to conventional therapies for IBD.
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spelling pubmed-99687232023-02-28 Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice Manna, Laura Rizzi, Eleonora Bafile, Eleonora Cappelleri, Andrea Ruscica, Massimiliano Macchi, Chiara Podaliri Vulpiani, Michele Salini, Romolo Rossi, Emanuela Panebianco, Concetta Perri, Francesco Pazienza, Valerio Federici, Federica Front Nutr Nutrition INTRODUCTION: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that typically involve diarrhea, abdominal pain, fatigue, and weight loss, with a dramatic impact on patients’ quality of life. Standard medications are often associated with adverse side effects. Thus, alternative treatments such as probiotics are of great interest. The purpose of the present study was to evaluate the effects of oral administration of Lentilactobacillus kefiri (basonym: Lactobacillus kefiri) SGL 13 and Andrographis paniculata, namely, Paniculin 13™, on dextran sodium sulfate (DSS)- treated C57BL/6J mice. METHODS: Colitis was induced by administering 1.5% DSS in drinking water for 9 days. Forty male mice were divided into four groups, receiving PBS (control), 1.5% DSS, Paniculin 13™ and 1.5% DSS + Paniculin 13™. RESULTS: The results showed that body weight loss and Disease Activity Index (DAI) score were improved by Paniculin 13™. Moreover, Paniculin 13™ ameliorated DSS-induced dysbiosis, by modulating the gut microbiota composition. The gene expression of MPO, TNFα and iNOS in colon tissue was reduced and these data matched with the histological results, supporting the efficacy of Paniculin 13™ in reducing the inflammatory response. No adverse effects were associated to Paniculin 13™ administration. DISCUSSION: In conclusion, Paniculin 13™ could be an effective add-on approach to conventional therapies for IBD. Frontiers Media S.A. 2023-02-13 /pmc/articles/PMC9968723/ /pubmed/36860688 http://dx.doi.org/10.3389/fnut.2023.1072334 Text en Copyright © 2023 Manna, Rizzi, Bafile, Cappelleri, Ruscica, Macchi, Podaliri Vulpiani, Salini, Rossi, Panebianco, Perri, Pazienza and Federici. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Manna, Laura
Rizzi, Eleonora
Bafile, Eleonora
Cappelleri, Andrea
Ruscica, Massimiliano
Macchi, Chiara
Podaliri Vulpiani, Michele
Salini, Romolo
Rossi, Emanuela
Panebianco, Concetta
Perri, Francesco
Pazienza, Valerio
Federici, Federica
Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
title Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
title_full Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
title_fullStr Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
title_full_unstemmed Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
title_short Lentilactobacillus kefiri SGL 13 and Andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
title_sort lentilactobacillus kefiri sgl 13 and andrographis paniculata alleviate dextran sulfate sodium induced colitis in mice
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968723/
https://www.ncbi.nlm.nih.gov/pubmed/36860688
http://dx.doi.org/10.3389/fnut.2023.1072334
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