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Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight

Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot...

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Autores principales: Hussain, Tarique, Kandeel, Mahmoud, Metwally, Elsayed, Murtaza, Ghulam, Kalhoro, Dildar Hussain, Yin, Yulong, Tan, Bie, Chughtai, Muhammad Ismail, Yaseen, Anjaleena, Afzal, Ali, Kalhoro, Muhammad Saleem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968806/
https://www.ncbi.nlm.nih.gov/pubmed/36860366
http://dx.doi.org/10.3389/fendo.2023.1070692
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author Hussain, Tarique
Kandeel, Mahmoud
Metwally, Elsayed
Murtaza, Ghulam
Kalhoro, Dildar Hussain
Yin, Yulong
Tan, Bie
Chughtai, Muhammad Ismail
Yaseen, Anjaleena
Afzal, Ali
Kalhoro, Muhammad Saleem
author_facet Hussain, Tarique
Kandeel, Mahmoud
Metwally, Elsayed
Murtaza, Ghulam
Kalhoro, Dildar Hussain
Yin, Yulong
Tan, Bie
Chughtai, Muhammad Ismail
Yaseen, Anjaleena
Afzal, Ali
Kalhoro, Muhammad Saleem
author_sort Hussain, Tarique
collection PubMed
description Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot be controlled by the antioxidant system and, thus, potentially impact male fertility and hamper sperm quality parameters. Mitochondria are the driving force of sperm motility; irregularities in their function may lead to apoptosis, alterations to signaling pathway function, and, ultimately, compromised fertility. Moreover, it has been observed that the prevalence of inflammation may arrest sperm function and the production of cytokines triggered by the overproduction of ROS. Further, oxidative stress interacts with seminal plasma proteomes that influence male fertility. Enhanced ROS production disturbs the cellular constituents, particularly DNA, and sperms are unable to impregnate the ovum. Here, we review the latest information to better understand the relationship between oxidative stress and male infertility, the role of mitochondria, the cellular response, inflammation and fertility, and the interaction of seminal plasma proteomes with oxidative stress, as well as highlight the influence of oxidative stress on hormones; collectively, all of these factors are assumed to be important for the regulation of male infertility. This article may help improve our understanding of male infertility and the strategies to prevent it.
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spelling pubmed-99688062023-02-28 Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight Hussain, Tarique Kandeel, Mahmoud Metwally, Elsayed Murtaza, Ghulam Kalhoro, Dildar Hussain Yin, Yulong Tan, Bie Chughtai, Muhammad Ismail Yaseen, Anjaleena Afzal, Ali Kalhoro, Muhammad Saleem Front Endocrinol (Lausanne) Endocrinology Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot be controlled by the antioxidant system and, thus, potentially impact male fertility and hamper sperm quality parameters. Mitochondria are the driving force of sperm motility; irregularities in their function may lead to apoptosis, alterations to signaling pathway function, and, ultimately, compromised fertility. Moreover, it has been observed that the prevalence of inflammation may arrest sperm function and the production of cytokines triggered by the overproduction of ROS. Further, oxidative stress interacts with seminal plasma proteomes that influence male fertility. Enhanced ROS production disturbs the cellular constituents, particularly DNA, and sperms are unable to impregnate the ovum. Here, we review the latest information to better understand the relationship between oxidative stress and male infertility, the role of mitochondria, the cellular response, inflammation and fertility, and the interaction of seminal plasma proteomes with oxidative stress, as well as highlight the influence of oxidative stress on hormones; collectively, all of these factors are assumed to be important for the regulation of male infertility. This article may help improve our understanding of male infertility and the strategies to prevent it. Frontiers Media S.A. 2023-02-13 /pmc/articles/PMC9968806/ /pubmed/36860366 http://dx.doi.org/10.3389/fendo.2023.1070692 Text en Copyright © 2023 Hussain, Kandeel, Metwally, Murtaza, Kalhoro, Yin, Tan, Chughtai, Yaseen, Afzal and Kalhoro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hussain, Tarique
Kandeel, Mahmoud
Metwally, Elsayed
Murtaza, Ghulam
Kalhoro, Dildar Hussain
Yin, Yulong
Tan, Bie
Chughtai, Muhammad Ismail
Yaseen, Anjaleena
Afzal, Ali
Kalhoro, Muhammad Saleem
Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
title Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
title_full Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
title_fullStr Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
title_full_unstemmed Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
title_short Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
title_sort unraveling the harmful effect of oxidative stress on male fertility: a mechanistic insight
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968806/
https://www.ncbi.nlm.nih.gov/pubmed/36860366
http://dx.doi.org/10.3389/fendo.2023.1070692
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