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Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight
Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968806/ https://www.ncbi.nlm.nih.gov/pubmed/36860366 http://dx.doi.org/10.3389/fendo.2023.1070692 |
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author | Hussain, Tarique Kandeel, Mahmoud Metwally, Elsayed Murtaza, Ghulam Kalhoro, Dildar Hussain Yin, Yulong Tan, Bie Chughtai, Muhammad Ismail Yaseen, Anjaleena Afzal, Ali Kalhoro, Muhammad Saleem |
author_facet | Hussain, Tarique Kandeel, Mahmoud Metwally, Elsayed Murtaza, Ghulam Kalhoro, Dildar Hussain Yin, Yulong Tan, Bie Chughtai, Muhammad Ismail Yaseen, Anjaleena Afzal, Ali Kalhoro, Muhammad Saleem |
author_sort | Hussain, Tarique |
collection | PubMed |
description | Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot be controlled by the antioxidant system and, thus, potentially impact male fertility and hamper sperm quality parameters. Mitochondria are the driving force of sperm motility; irregularities in their function may lead to apoptosis, alterations to signaling pathway function, and, ultimately, compromised fertility. Moreover, it has been observed that the prevalence of inflammation may arrest sperm function and the production of cytokines triggered by the overproduction of ROS. Further, oxidative stress interacts with seminal plasma proteomes that influence male fertility. Enhanced ROS production disturbs the cellular constituents, particularly DNA, and sperms are unable to impregnate the ovum. Here, we review the latest information to better understand the relationship between oxidative stress and male infertility, the role of mitochondria, the cellular response, inflammation and fertility, and the interaction of seminal plasma proteomes with oxidative stress, as well as highlight the influence of oxidative stress on hormones; collectively, all of these factors are assumed to be important for the regulation of male infertility. This article may help improve our understanding of male infertility and the strategies to prevent it. |
format | Online Article Text |
id | pubmed-9968806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99688062023-02-28 Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight Hussain, Tarique Kandeel, Mahmoud Metwally, Elsayed Murtaza, Ghulam Kalhoro, Dildar Hussain Yin, Yulong Tan, Bie Chughtai, Muhammad Ismail Yaseen, Anjaleena Afzal, Ali Kalhoro, Muhammad Saleem Front Endocrinol (Lausanne) Endocrinology Male infertility is a widely debated issue that affects males globally. There are several mechanisms involved. Oxidative stress is accepted to be the main contributing factor, with sperm quality and quantity affected by the overproduction of free radicals. Excess reactive oxygen species (ROS) cannot be controlled by the antioxidant system and, thus, potentially impact male fertility and hamper sperm quality parameters. Mitochondria are the driving force of sperm motility; irregularities in their function may lead to apoptosis, alterations to signaling pathway function, and, ultimately, compromised fertility. Moreover, it has been observed that the prevalence of inflammation may arrest sperm function and the production of cytokines triggered by the overproduction of ROS. Further, oxidative stress interacts with seminal plasma proteomes that influence male fertility. Enhanced ROS production disturbs the cellular constituents, particularly DNA, and sperms are unable to impregnate the ovum. Here, we review the latest information to better understand the relationship between oxidative stress and male infertility, the role of mitochondria, the cellular response, inflammation and fertility, and the interaction of seminal plasma proteomes with oxidative stress, as well as highlight the influence of oxidative stress on hormones; collectively, all of these factors are assumed to be important for the regulation of male infertility. This article may help improve our understanding of male infertility and the strategies to prevent it. Frontiers Media S.A. 2023-02-13 /pmc/articles/PMC9968806/ /pubmed/36860366 http://dx.doi.org/10.3389/fendo.2023.1070692 Text en Copyright © 2023 Hussain, Kandeel, Metwally, Murtaza, Kalhoro, Yin, Tan, Chughtai, Yaseen, Afzal and Kalhoro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Hussain, Tarique Kandeel, Mahmoud Metwally, Elsayed Murtaza, Ghulam Kalhoro, Dildar Hussain Yin, Yulong Tan, Bie Chughtai, Muhammad Ismail Yaseen, Anjaleena Afzal, Ali Kalhoro, Muhammad Saleem Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight |
title | Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight |
title_full | Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight |
title_fullStr | Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight |
title_full_unstemmed | Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight |
title_short | Unraveling the harmful effect of oxidative stress on male fertility: A mechanistic insight |
title_sort | unraveling the harmful effect of oxidative stress on male fertility: a mechanistic insight |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968806/ https://www.ncbi.nlm.nih.gov/pubmed/36860366 http://dx.doi.org/10.3389/fendo.2023.1070692 |
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