The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury

BACKGROUND: Calcineurin inhibitors (CNIs) are associated with nephrotoxicity, endothelial cell dysfunction, and thrombotic microangiopathy (TMA). Evolving evidence suggests an important role for complement dysregulation in the pathogenesis of CNI-induced TMA. However, the exact mechanism(s) of CNI-i...

Descripción completa

Detalles Bibliográficos
Autores principales: Teoh, Chia Wei, Riedl Khursigara, Magdalena, Ortiz-Sandoval, Carolina G., Park, Jee Woo, Li, Jun, Bohorquez-Hernandez, Arlette, Bruno, Valentina, Bowen, Emily E., Freeman, Spencer A., Robinson, Lisa A., Licht, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968885/
https://www.ncbi.nlm.nih.gov/pubmed/36860338
http://dx.doi.org/10.3389/fmed.2023.891513

Ejemplares similares

Ejemplares similares