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Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study
Background. Concurrent coronavirus disease 2019 (COVID-19) and Pneumocystis jirovecii pneumonia (PJP) has been described in various reports, with a recent study describing a 9.3 % P. jirovecii detection rate in critically ill COVID-19 patients. Methods. Patients with PCR-confirmed PJP following COVI...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Microbiology Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968954/ https://www.ncbi.nlm.nih.gov/pubmed/36860506 http://dx.doi.org/10.1099/acmi.0.000406 |
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author | Niamatullah, Hammad Nasir, Nosheen Jabeen, Kauser Rattani, Salima Farooqi, Joveria Ghanchi, Najia Irfan, Muhammad |
author_facet | Niamatullah, Hammad Nasir, Nosheen Jabeen, Kauser Rattani, Salima Farooqi, Joveria Ghanchi, Najia Irfan, Muhammad |
author_sort | Niamatullah, Hammad |
collection | PubMed |
description | Background. Concurrent coronavirus disease 2019 (COVID-19) and Pneumocystis jirovecii pneumonia (PJP) has been described in various reports, with a recent study describing a 9.3 % P. jirovecii detection rate in critically ill COVID-19 patients. Methods. Patients with PCR-confirmed PJP following COVID-19 infection who were admitted to Aga Khan University Hospital, Karachi, Pakistan from March 2020–June 2021 were identified through a laboratory database. Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was performed by RT-PCR Cobas SARS-CoV-2 qualitative assay. P. jirovecii PCR was performed using the RealStar Pneumocystis jirovecii PCR kit. Clinical, radiological and laboratory data for PJP patients were recorded. Results. During the study period, 3707 patients were admitted with COVID-19 at our hospital. P. jirovecii PCR was requested for 90 patients and was positive in 10 (11 %). Five out of 10 patients were discharged from the hospital and later developed cough and dyspnoea. Five patients remained hospitalized with severe COVID-19 and developed PJP. Eight patients in our study received systemic steroids. The trends of lymphocyte counts of all patients showed a lymphocyte count of <1000 mm(−3) (<1.0×10(6) cells µl(−1)) in the week of PJP diagnosis. Four patients did not survive; one of these patients did not receive co-trimoxazole due to late diagnosis, one patient had concomitant nosocomial pneumonia and bacteraemia with multidrug-resistant Acinetobacter species, and two patients had concomitant aspergillosis. Conclusion. In summary, invasive fungal infections such as PJP should be considered as a complication in COVID-19 patients, with prompt evaluation and management. |
format | Online Article Text |
id | pubmed-9968954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Microbiology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99689542023-02-28 Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study Niamatullah, Hammad Nasir, Nosheen Jabeen, Kauser Rattani, Salima Farooqi, Joveria Ghanchi, Najia Irfan, Muhammad Access Microbiol Short Communications Background. Concurrent coronavirus disease 2019 (COVID-19) and Pneumocystis jirovecii pneumonia (PJP) has been described in various reports, with a recent study describing a 9.3 % P. jirovecii detection rate in critically ill COVID-19 patients. Methods. Patients with PCR-confirmed PJP following COVID-19 infection who were admitted to Aga Khan University Hospital, Karachi, Pakistan from March 2020–June 2021 were identified through a laboratory database. Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was performed by RT-PCR Cobas SARS-CoV-2 qualitative assay. P. jirovecii PCR was performed using the RealStar Pneumocystis jirovecii PCR kit. Clinical, radiological and laboratory data for PJP patients were recorded. Results. During the study period, 3707 patients were admitted with COVID-19 at our hospital. P. jirovecii PCR was requested for 90 patients and was positive in 10 (11 %). Five out of 10 patients were discharged from the hospital and later developed cough and dyspnoea. Five patients remained hospitalized with severe COVID-19 and developed PJP. Eight patients in our study received systemic steroids. The trends of lymphocyte counts of all patients showed a lymphocyte count of <1000 mm(−3) (<1.0×10(6) cells µl(−1)) in the week of PJP diagnosis. Four patients did not survive; one of these patients did not receive co-trimoxazole due to late diagnosis, one patient had concomitant nosocomial pneumonia and bacteraemia with multidrug-resistant Acinetobacter species, and two patients had concomitant aspergillosis. Conclusion. In summary, invasive fungal infections such as PJP should be considered as a complication in COVID-19 patients, with prompt evaluation and management. Microbiology Society 2023-01-05 /pmc/articles/PMC9968954/ /pubmed/36860506 http://dx.doi.org/10.1099/acmi.0.000406 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. |
spellingShingle | Short Communications Niamatullah, Hammad Nasir, Nosheen Jabeen, Kauser Rattani, Salima Farooqi, Joveria Ghanchi, Najia Irfan, Muhammad Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study |
title | Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study |
title_full | Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study |
title_fullStr | Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study |
title_full_unstemmed | Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study |
title_short | Post-COVID-19 Pneumocystis pneumonia cases from Pakistan: an observational study |
title_sort | post-covid-19 pneumocystis pneumonia cases from pakistan: an observational study |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968954/ https://www.ncbi.nlm.nih.gov/pubmed/36860506 http://dx.doi.org/10.1099/acmi.0.000406 |
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