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A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors
Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP. Inhibiting the activity of PDE5A has proven to be an effective strategy for treating pulmonary arterial hypertension and erect...
Autores principales: | Ma, Yufeng, Zhang, Fengsen, Zhong, Yijing, Huang, Yongchun, Yixizhuoma, Jia, Qiangqiang, Zhang, Shoude |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968969/ https://www.ncbi.nlm.nih.gov/pubmed/36860644 http://dx.doi.org/10.3389/fchem.2023.1097027 |
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