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A label-free LC/MS-based enzymatic activity assay for the detection of PDE5A inhibitors

Phosphodiesterase type 5 (PDE5), a cyclic nucleotide phosphodiesterase, controls the duration of the cyclic guanosine monophosphate (cGMP) signal by hydrolyzing cGMP to GMP. Inhibiting the activity of PDE5A has proven to be an effective strategy for treating pulmonary arterial hypertension and erect...

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Detalles Bibliográficos
Autores principales:	Ma, Yufeng, Zhang, Fengsen, Zhong, Yijing, Huang, Yongchun, Yixizhuoma, Jia, Qiangqiang, Zhang, Shoude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968969/ https://www.ncbi.nlm.nih.gov/pubmed/36860644 http://dx.doi.org/10.3389/fchem.2023.1097027

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