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Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers

Due to recalcitrant microangiopathy and chronic infection, traditional treatments do not easily produce satisfactory results for chronic diabetic ulcers. In recent years, due to the advantages of high biocompatibility and modifiability, an increasing number of hydrogel materials have been applied to...

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Autores principales: Cui, Jiaming, Zhang, Siqi, Cheng, Songmiao, Shen, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968980/
https://www.ncbi.nlm.nih.gov/pubmed/36860881
http://dx.doi.org/10.3389/fbioe.2023.1077490
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author Cui, Jiaming
Zhang, Siqi
Cheng, Songmiao
Shen, Hai
author_facet Cui, Jiaming
Zhang, Siqi
Cheng, Songmiao
Shen, Hai
author_sort Cui, Jiaming
collection PubMed
description Due to recalcitrant microangiopathy and chronic infection, traditional treatments do not easily produce satisfactory results for chronic diabetic ulcers. In recent years, due to the advantages of high biocompatibility and modifiability, an increasing number of hydrogel materials have been applied to the treatment of chronic wounds in diabetic patients. Research on composite hydrogels has received increasing attention since loading different components can greatly increase the ability of composite hydrogels to treat chronic diabetic wounds. This review summarizes and details a variety of newly loaded components currently used in hydrogel composites for the treatment of chronic diabetic ulcers, such as polymer/polysaccharides/organic chemicals, stem cells/exosomes/progenitor cells, chelating agents/metal ions, plant extracts, proteins (cytokines/peptides/enzymes) and nucleoside products, and medicines/drugs, to help researchers understand the characteristics of these components in the treatment of diabetic chronic wounds. This review also discusses a number of components that have not yet been applied but have the potential to be loaded into hydrogels, all of which play roles in the biomedical field and may become important loading components in the future. This review provides a “loading component shelf” for researchers of composite hydrogels and a theoretical basis for the future construction of “all-in-one” hydrogels.
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spelling pubmed-99689802023-02-28 Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers Cui, Jiaming Zhang, Siqi Cheng, Songmiao Shen, Hai Front Bioeng Biotechnol Bioengineering and Biotechnology Due to recalcitrant microangiopathy and chronic infection, traditional treatments do not easily produce satisfactory results for chronic diabetic ulcers. In recent years, due to the advantages of high biocompatibility and modifiability, an increasing number of hydrogel materials have been applied to the treatment of chronic wounds in diabetic patients. Research on composite hydrogels has received increasing attention since loading different components can greatly increase the ability of composite hydrogels to treat chronic diabetic wounds. This review summarizes and details a variety of newly loaded components currently used in hydrogel composites for the treatment of chronic diabetic ulcers, such as polymer/polysaccharides/organic chemicals, stem cells/exosomes/progenitor cells, chelating agents/metal ions, plant extracts, proteins (cytokines/peptides/enzymes) and nucleoside products, and medicines/drugs, to help researchers understand the characteristics of these components in the treatment of diabetic chronic wounds. This review also discusses a number of components that have not yet been applied but have the potential to be loaded into hydrogels, all of which play roles in the biomedical field and may become important loading components in the future. This review provides a “loading component shelf” for researchers of composite hydrogels and a theoretical basis for the future construction of “all-in-one” hydrogels. Frontiers Media S.A. 2023-02-13 /pmc/articles/PMC9968980/ /pubmed/36860881 http://dx.doi.org/10.3389/fbioe.2023.1077490 Text en Copyright © 2023 Cui, Zhang, Cheng and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Cui, Jiaming
Zhang, Siqi
Cheng, Songmiao
Shen, Hai
Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
title Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
title_full Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
title_fullStr Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
title_full_unstemmed Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
title_short Current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
title_sort current and future outlook of loaded components in hydrogel composites for the treatment of chronic diabetic ulcers
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968980/
https://www.ncbi.nlm.nih.gov/pubmed/36860881
http://dx.doi.org/10.3389/fbioe.2023.1077490
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