USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

Adenomatous polyposis coli (APC) mutation is the hallmark of colorectal cancer (CRC), resulting in constitutive WNT activation. Despite decades of research, targeting WNT signaling in cancer remains challenging due to its on-target toxicity. We have previously shown that the deubiquitinating enzyme...

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Detalles Bibliográficos
Autores principales: Novellasdemunt, Laura, Kucharska, Anna, Baulies, Anna, Hutton, Colin, Vlachogiannis, Georgios, Repana, Dimitra, Rowan, Andrew, Suárez-Bonnet, A., Ciccarelli, Francesca, Valeri, Nicola, Li, Vivian S.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968985/
https://www.ncbi.nlm.nih.gov/pubmed/36669491
http://dx.doi.org/10.1016/j.stemcr.2022.12.013

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