Cargando…

A pluripotent developmental state confers a low fidelity of chromosome segregation

During in vitro propagation, human pluripotent stem cells (hPSCs) frequently become aneuploid with incorrect chromosome numbers due to mitotic chromosome segregation errors. Yet, it is not understood why hPSCs exhibit a low mitotic fidelity. Here, we investigate the mechanisms responsible for mitoti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Chenhui, Ya, Amanda, Compton, Duane A., Godek, Kristina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968987/ https://www.ncbi.nlm.nih.gov/pubmed/36638786 http://dx.doi.org/10.1016/j.stemcr.2022.12.008

Ejemplares similares

Ensuring fidelity of chromosome segregation
por: Ünal, Elçin, et al.
Publicado: (2018)

An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity
por: Kucharski, Thomas J., et al.
Publicado: (2023)

Cyclin A Regulates Kinetochore-Microtubules to Promote Faithful Chromosome Segregation
por: Kabeche, Lilian, et al.
Publicado: (2013)

Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11
por: Zadra, Ivan, et al.
Publicado: (2022)

Advances in imaging reveal novel insights into the mechanisms promoting accurate chromosome segregation in mitosis and meiosis
por: Compton, Duane, et al.
Publicado: (2011)

Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation
por: Liang, Cai, et al.
Publicado: (2019)

An Aurora B-RPA signaling axis secures chromosome segregation fidelity
por: Roshan, Poonam, et al.
Publicado: (2023)

Small changes in phospho-occupancy at the kinetochore–microtubule interface drive mitotic fidelity
por: Kucharski, Thomas J., et al.
Publicado: (2022)

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells
por: Zhao, Yanding, et al.
Publicado: (2019)

Fission Yeast Methylenetetrahydrofolate Reductase Ensures Mitotic and Meiotic Chromosome Segregation Fidelity
por: Lim, Kim Kiat, et al.
Publicado: (2021)

Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation
por: Sundararajan, Sanjana, et al.
Publicado: (2023)

Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation
por: Hood, Emily A., et al.
Publicado: (2012)

Satellite DNA at the Centromere Is Dispensable for Segregation Fidelity
por: Roberti, Annalisa, et al.
Publicado: (2019)

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2
por: Kim, Jung-Sik, et al.
Publicado: (2016)

Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation
por: Cunha-Silva, Sofia, et al.
Publicado: (2020)

Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast
por: Mishra, Prashant K., et al.
Publicado: (2021)

Chromosome orientation
por: Compton, Duane A.
Publicado: (2007)

Asymmetric Strand Segregation: Epigenetic Costs of Genetic Fidelity?
por: Genereux, Diane P.
Publicado: (2009)

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern
por: Berchowitz, Luke E., et al.
Publicado: (2013)

Measuring site fidelity and spatial segregation within animal societies
por: Richardson, Thomas O., et al.
Publicado: (2017)

Cohesin and chromosome segregation
por: Makrantoni, Vasso, et al.
Publicado: (2018)

An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation
por: Matsuo, Yuzy, et al.
Publicado: (2016)

Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen Cryptococcus neoformans
por: Yadav, Vikas, et al.
Publicado: (2018)

P38 Mitogen-activated Protein Kinase Activity Is Required during Mitosis for Timely Satisfaction of the Mitotic Checkpoint But Not for the Fidelity of Chromosome Segregation
por: Lee, Kyunghee, et al.
Publicado: (2010)

TELOPHASE SEGREGATION OF CHROMOSOMES AND AMITOSIS
por: Molè-Bajer, J.
Publicado: (1965)

For chromosomes, equality means segregation
por: Leslie, Mitch
Publicado: (2009)

Chromosome Segregation: Disarming the Protector
por: Sanyal, Swastika, et al.
Publicado: (2013)

Chromosome segregation in plant meiosis
por: Zamariola, Linda, et al.
Publicado: (2014)

Spindle mechanics and chromosome segregation
por: Tolić, Iva M., et al.
Publicado: (2019)

Mechanical Mechanisms of Chromosome Segregation
por: Anjur-Dietrich, Maya I., et al.
Publicado: (2021)

Mechanisms for Chromosome Segregation in Bacteria
por: Gogou, Christos, et al.
Publicado: (2021)

Double-checking chromosome segregation
por: Maiato, Helder, et al.
Publicado: (2023)

Compromised Mitotic Fidelity in Human Pluripotent Stem Cells
por: Milagre, Inês, et al.
Publicado: (2023)

Sth1, the Key Subunit of the RSC Chromatin Remodeling Complex, Is Essential in Maintaining Chromosomal Integrity and Mediating High Fidelity Chromosome Segregation in the Human Fungal Pathogen Candida albicans
por: Prasad, Priya, et al.
Publicado: (2019)

Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation
por: Carvalhal, Sara, et al.
Publicado: (2022)

Examining the link between chromosomal instability and aneuploidy in human cells
por: Thompson, Sarah L., et al.
Publicado: (2008)

Searching for the middle ground: mechanisms of chromosome alignment during mitosis
por: Kapoor, Tarun M., et al.
Publicado: (2002)

Asymmetric chromosome segregation in Xanthomonas citri ssp. citri
por: Ucci, Amanda P, et al.
Publicado: (2014)

Modeling heterogeneity in the pluripotent state: A promising strategy for improving the efficiency and fidelity of stem cell differentiation
por: Espinosa Angarica, Vladimir, et al.
Publicado: (2016)

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation
por: Huang, Daosheng, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6eqe0qal7qbsb3ie8i84lbdva1