New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants

[Image: see text] We disclose here a panel of small-molecule TLR4 agonists (the FP20 series) whose structure is derived from previously developed TLR4 ligands (FP18 series). The new molecules have increased chemical stability and a shorter, more efficient, and scalable synthesis. The FP20 series sho...

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Detalles Bibliográficos
Autores principales: Romerio, Alessio, Gotri, Nicole, Franco, Ana Rita, Artusa, Valentina, Shaik, Mohammed Monsoor, Pasco, Samuel T., Atxabal, Unai, Matamoros-Recio, Alejandra, Mínguez-Toral, Marina, Zalamea, Juan Diego, Franconetti, Antonio, Abrescia, Nicola G. A., Jimenez-Barbero, Jesus, Anguita, Juan, Martín-Santamaría, Sonsoles, Peri, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969399/
https://www.ncbi.nlm.nih.gov/pubmed/36728697
http://dx.doi.org/10.1021/acs.jmedchem.2c01998

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