An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8(+) T cells

Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active variant of toll-like receptor 4 and the co-sti...

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Detalles Bibliográficos
Autores principales: de Mey, Wout, Locy, Hanne, De Ridder, Kirsten, De Schrijver, Phaedra, Autaers, Dorien, Lakdimi, Asma, Esprit, Arthur, Franceschini, Lorenzo, Thielemans, Kris, Verdonck, Magali, Breckpot, Karine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969480/
https://www.ncbi.nlm.nih.gov/pubmed/36860873
http://dx.doi.org/10.3389/fimmu.2023.1111523

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