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S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most common and malignant liver tumor worldwide, although the treatment approaches for HCC continue to evolve, metastasis is the main reason for high mortality rates. S100 calcium-binding protein A11 (S100A11), an important member of the S100 family of small cal...

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Autores principales: Zheng, Mei, Meng, Huan, Li, Yunhui, Shi, Jingren, Han, Ying, Zhao, Changxu, Chen, Jin, Han, Jinyu, Liang, Jing, Chen, Yuan, Liu, Qiqi, Wang, Yajie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969497/
https://www.ncbi.nlm.nih.gov/pubmed/36860671
http://dx.doi.org/10.7150/ijms.80503
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author Zheng, Mei
Meng, Huan
Li, Yunhui
Shi, Jingren
Han, Ying
Zhao, Changxu
Chen, Jin
Han, Jinyu
Liang, Jing
Chen, Yuan
Liu, Qiqi
Wang, Yajie
author_facet Zheng, Mei
Meng, Huan
Li, Yunhui
Shi, Jingren
Han, Ying
Zhao, Changxu
Chen, Jin
Han, Jinyu
Liang, Jing
Chen, Yuan
Liu, Qiqi
Wang, Yajie
author_sort Zheng, Mei
collection PubMed
description Hepatocellular carcinoma (HCC) is the most common and malignant liver tumor worldwide, although the treatment approaches for HCC continue to evolve, metastasis is the main reason for high mortality rates. S100 calcium-binding protein A11 (S100A11), an important member of the S100 family of small calcium-binding proteins, is overexpressed in various cells and regulates tumor development and metastasis. However, few studies report the role and underlying regulatory mechanisms of S100A11 in HCC development and metastasis. Herein, we discovered that S100A11 is overexpressed and associated with poor clinical outcomes in HCC cohorts, and we provided the first demonstration that S100A11 could serve as a novel diagnostic biomarker used in conjunction with AFP for HCC. Further analysis implied that S100A11 outperforms AFP in determining whether HCC patients have hematogenous metastasis or not. Using in vitro cell culture model, we demonstrated that S100A11 is overexpressed in metastatic hepatoma cells, knockdown of S100A11 decreases hepatoma cells proliferation, migration, invasion, and epithelial-mesenchymal transition process by inhibiting AKT and ERK signaling pathways. Altogether, our study provides new sights into the biological function and mechanisms underlying S100A11 in promoting metastasis of HCC and explores a novel target for HCC diagnosis and treatment.
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spelling pubmed-99694972023-02-28 S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma Zheng, Mei Meng, Huan Li, Yunhui Shi, Jingren Han, Ying Zhao, Changxu Chen, Jin Han, Jinyu Liang, Jing Chen, Yuan Liu, Qiqi Wang, Yajie Int J Med Sci Research Paper Hepatocellular carcinoma (HCC) is the most common and malignant liver tumor worldwide, although the treatment approaches for HCC continue to evolve, metastasis is the main reason for high mortality rates. S100 calcium-binding protein A11 (S100A11), an important member of the S100 family of small calcium-binding proteins, is overexpressed in various cells and regulates tumor development and metastasis. However, few studies report the role and underlying regulatory mechanisms of S100A11 in HCC development and metastasis. Herein, we discovered that S100A11 is overexpressed and associated with poor clinical outcomes in HCC cohorts, and we provided the first demonstration that S100A11 could serve as a novel diagnostic biomarker used in conjunction with AFP for HCC. Further analysis implied that S100A11 outperforms AFP in determining whether HCC patients have hematogenous metastasis or not. Using in vitro cell culture model, we demonstrated that S100A11 is overexpressed in metastatic hepatoma cells, knockdown of S100A11 decreases hepatoma cells proliferation, migration, invasion, and epithelial-mesenchymal transition process by inhibiting AKT and ERK signaling pathways. Altogether, our study provides new sights into the biological function and mechanisms underlying S100A11 in promoting metastasis of HCC and explores a novel target for HCC diagnosis and treatment. Ivyspring International Publisher 2023-01-31 /pmc/articles/PMC9969497/ /pubmed/36860671 http://dx.doi.org/10.7150/ijms.80503 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zheng, Mei
Meng, Huan
Li, Yunhui
Shi, Jingren
Han, Ying
Zhao, Changxu
Chen, Jin
Han, Jinyu
Liang, Jing
Chen, Yuan
Liu, Qiqi
Wang, Yajie
S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
title S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
title_full S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
title_fullStr S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
title_full_unstemmed S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
title_short S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma
title_sort s100a11 promotes metastasis via akt and erk signaling pathways and has a diagnostic role in hepatocellular carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969497/
https://www.ncbi.nlm.nih.gov/pubmed/36860671
http://dx.doi.org/10.7150/ijms.80503
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