Research Progress on N(6)-adenosylate Methylation RNA Modification in Heart Failure Remodeling

Cardiovascular disease (CVD) is the major cause of disability-adjusted life years (DALY) and death globally. The most common internal modification of mRNA is N(6)-adenosylate methylation (m(6)A). Recently, a growing number of studies have been devoted to researching cardiac remodeling mechanisms, especially m(6)A RNA methylation, revealing a connection between m(6)A and cardiovascular diseases. This review summarized the current understanding regarding m(6)A and elucidated the dynamic modifications of writers, erasers, and readers. Furthermore, we highlighted m(6)A RNA methylation related to cardiac remodeling and summarized its potential mechanisms. Finally, we discussed the potential of m(6)A RNA methylation in the treatment of cardiac remodeling.