High-efficiency production of the antimicrobial peptide pediocin PA-1 in metabolically engineered Corynebacterium glutamicum using a microaerobic process at acidic pH and elevated levels of bivalent calcium ions

BACKGROUND: Pediocin PA-1 is a bacteriocin of recognized value with applications in food bio-preservation and the medical sector for the prevention of infection. To date, industrial manufacturing of pediocin PA-1 is limited by high cost and low-performance. The recent establishment of the biotechnol...

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Detalles Bibliográficos
Autores principales: Christmann, Jens, Cao, Peng, Becker, Judith, Desiderato, Christian K., Goldbeck, Oliver, Riedel, Christian U., Kohlstedt, Michael, Wittmann, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969654/
https://www.ncbi.nlm.nih.gov/pubmed/36849884
http://dx.doi.org/10.1186/s12934-023-02044-y

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