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Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has the sixth-highest new incidence and fourth-highest mortality worldwide. Transarterial chemoembolization (TACE) is one of the primary treatment strategies for unresectable HCC. However, the therapeutic effect is still unsatisfactory due to the insufficient distribut...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969656/ https://www.ncbi.nlm.nih.gov/pubmed/36849981 http://dx.doi.org/10.1186/s12951-023-01820-7 |
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author | Yuan, Gang Liu, Zhiyin Wang, Weiming Liu, Mengnan Xu, Yanneng Hu, Wei Fan, Yao Zhang, Xun Liu, Yong Si, Guangyan |
author_facet | Yuan, Gang Liu, Zhiyin Wang, Weiming Liu, Mengnan Xu, Yanneng Hu, Wei Fan, Yao Zhang, Xun Liu, Yong Si, Guangyan |
author_sort | Yuan, Gang |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) has the sixth-highest new incidence and fourth-highest mortality worldwide. Transarterial chemoembolization (TACE) is one of the primary treatment strategies for unresectable HCC. However, the therapeutic effect is still unsatisfactory due to the insufficient distribution of antineoplastic drugs in tumor tissues and the worsened post-embolization tumor microenvironment (TME, e.g., hypoxia and reduced pH). Recently, using nanomaterials as a drug delivery platform for TACE therapy of HCC has been a research hotspot. With the development of nanotechnology, multifunctional nanoplatforms have been developed to embolize the tumor vasculature, creating conditions for improving the distribution and bioavailability of drugs in tumor tissues. Currently, the researchers are focusing on functionalizing nanomaterials to achieve high drug loading efficacy, thorough vascular embolization, tumor targeting, controlled sustained release of drugs, and real-time imaging in the TACE process to facilitate precise embolization and enable therapeutic procedures follow-up imaging of tumor lesions. Herein, we summarized the recent advances and applications of functionalized nanomaterials based on TACE against HCC, believing that developing these functionalized nanoplatforms may be a promising approach for improving the TACE therapeutic effect of HCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01820-7. |
format | Online Article Text |
id | pubmed-9969656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99696562023-02-28 Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma Yuan, Gang Liu, Zhiyin Wang, Weiming Liu, Mengnan Xu, Yanneng Hu, Wei Fan, Yao Zhang, Xun Liu, Yong Si, Guangyan J Nanobiotechnology Review Hepatocellular carcinoma (HCC) has the sixth-highest new incidence and fourth-highest mortality worldwide. Transarterial chemoembolization (TACE) is one of the primary treatment strategies for unresectable HCC. However, the therapeutic effect is still unsatisfactory due to the insufficient distribution of antineoplastic drugs in tumor tissues and the worsened post-embolization tumor microenvironment (TME, e.g., hypoxia and reduced pH). Recently, using nanomaterials as a drug delivery platform for TACE therapy of HCC has been a research hotspot. With the development of nanotechnology, multifunctional nanoplatforms have been developed to embolize the tumor vasculature, creating conditions for improving the distribution and bioavailability of drugs in tumor tissues. Currently, the researchers are focusing on functionalizing nanomaterials to achieve high drug loading efficacy, thorough vascular embolization, tumor targeting, controlled sustained release of drugs, and real-time imaging in the TACE process to facilitate precise embolization and enable therapeutic procedures follow-up imaging of tumor lesions. Herein, we summarized the recent advances and applications of functionalized nanomaterials based on TACE against HCC, believing that developing these functionalized nanoplatforms may be a promising approach for improving the TACE therapeutic effect of HCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01820-7. BioMed Central 2023-02-27 /pmc/articles/PMC9969656/ /pubmed/36849981 http://dx.doi.org/10.1186/s12951-023-01820-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Yuan, Gang Liu, Zhiyin Wang, Weiming Liu, Mengnan Xu, Yanneng Hu, Wei Fan, Yao Zhang, Xun Liu, Yong Si, Guangyan Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
title | Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
title_full | Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
title_fullStr | Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
title_full_unstemmed | Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
title_short | Multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
title_sort | multifunctional nanoplatforms application in the transcatheter chemoembolization against hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969656/ https://www.ncbi.nlm.nih.gov/pubmed/36849981 http://dx.doi.org/10.1186/s12951-023-01820-7 |
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