The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C

BACKGROUND: Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclinical studies. The good safety profile of SpyADI renders thi...

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Detalles Bibliográficos
Autores principales: Linke, Charlotte, Freitag, Thomas, Riess, Christin, Scheffler, Jana Vanessa, del Moral, Katharina, Schoenwaelder, Nina, Fiedler, Tomas, Fiebig, Adina, Kaps, Philipp, Dubinski, Daniel, Schneider, Björn, Bergmann, Wendy, Classen, Carl Friedrich, Maletzki, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969664/
https://www.ncbi.nlm.nih.gov/pubmed/36843002
http://dx.doi.org/10.1186/s12935-023-02873-2

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