TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells

BACKGROUND: Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1β and downregulation of IL-1 receptor antagonist, the mechanism of which remains to be fully elucidated. Previous transcriptomic data identified differential expression of...

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Detalles Bibliográficos
Autores principales: Klück, Viola, Cabău, Georgiana, Mies, Linda, Bukkems, Femke, van Emst, Liesbeth, Bakker, René, van Caam, Arjan, Crişan, Tania O., Joosten, Leo A. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969669/
https://www.ncbi.nlm.nih.gov/pubmed/36850003
http://dx.doi.org/10.1186/s13075-023-03001-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969669/
https://www.ncbi.nlm.nih.gov/pubmed/36850003
http://dx.doi.org/10.1186/s13075-023-03001-1

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