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BDNF is altered in a brain-region specific manner and rescues deficits in Spinocerebellar Ataxia Type 1

Spinocerebellar ataxia type 1 (SCA1) is an adult-onset, dominantly inherited neurodegenerative disease caused by the expanded polyQ tract in the protein ATAXIN1 (ATXN1) and characterized by progressive motor and cognitive impairments. There are no disease-modifying treatments or cures for SCA1. Brai...

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Detalles Bibliográficos
Autores principales:	Rosa, Juao-Guilherme, Hamel, Katherine, Soles, Alyssa, Sheeler, Carrie, Borgenheimer, Ella, Gilliat, Stephen, Sbrocco, Kaelin, Ghanoum, Ferris, Handler, Hillary P., Forster, Colleen, Rainwater, Orion, Cvetanovic, Marija
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9969743/ https://www.ncbi.nlm.nih.gov/pubmed/36724861 http://dx.doi.org/10.1016/j.nbd.2023.106023

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