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Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients

OBJECTIVE: The aim of this study was to assess the laboratory performance of periostin associated with a panel of biomarkers to identify the inflammatory phenotype of Brazilian asthma patients. METHODS: We evaluated 103 Brazilian individuals, including 37 asthmatics and 66 nonasthmatic controls. Bot...

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Autores principales: Baldo, Danielle Cristiane, Romaldini, José Gustavo, Pizzichini, Marcia Margaret Menezes, Cançado, José Eduardo D., Dellavance, Alessandra, Stirbulov, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970379/
https://www.ncbi.nlm.nih.gov/pubmed/36753209
http://dx.doi.org/10.36416/1806-3756/e20220040
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author Baldo, Danielle Cristiane
Romaldini, José Gustavo
Pizzichini, Marcia Margaret Menezes
Cançado, José Eduardo D.
Dellavance, Alessandra
Stirbulov, Roberto
author_facet Baldo, Danielle Cristiane
Romaldini, José Gustavo
Pizzichini, Marcia Margaret Menezes
Cançado, José Eduardo D.
Dellavance, Alessandra
Stirbulov, Roberto
author_sort Baldo, Danielle Cristiane
collection PubMed
description OBJECTIVE: The aim of this study was to assess the laboratory performance of periostin associated with a panel of biomarkers to identify the inflammatory phenotype of Brazilian asthma patients. METHODS: We evaluated 103 Brazilian individuals, including 37 asthmatics and 66 nonasthmatic controls. Both groups underwent analyses for serum periostin, eosinophil levels in the peripheral blood, the fraction of exhaled nitric oxide (FeNO), total serum IgE, urinary leukotriene E(4), and serum cytokines. RESULTS: Higher levels of periostin (p = 0.005), blood eosinophils (p = 0.012), FeNO (p = 0.001), total IgE (p < 0.001), and IL-6 (p ≤ 0.001) were found in the asthmatic patients than the controls. Biomarker analyses by the ROC curve showed an AUC greater than 65%. Periostin (OR: 12,550; 95% CI: 2,498-63,063) and IL-6 (OR: 7,249; 95% CI: 1,737-30,262) revealed to be suitable asthma inflammation biomarkers. Blood eosinophils, FeNO, total IgE, IL-6, TNF, and IFN-g showed correlations with clinical severity characteristics in asthmatic patients. Periostin showed higher values in T2 asthma (p = 0.006) and TNF in non-T2 asthma (p = 0.029). CONCLUSION: The panel of biomarkers proposed for the identification of the inflammatory phenotype of asthmatic patients demonstrated good performance. Periostin proved to be an important biomarker for the identification of T2 asthma.
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spelling pubmed-99703792023-02-28 Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients Baldo, Danielle Cristiane Romaldini, José Gustavo Pizzichini, Marcia Margaret Menezes Cançado, José Eduardo D. Dellavance, Alessandra Stirbulov, Roberto J Bras Pneumol Original Article OBJECTIVE: The aim of this study was to assess the laboratory performance of periostin associated with a panel of biomarkers to identify the inflammatory phenotype of Brazilian asthma patients. METHODS: We evaluated 103 Brazilian individuals, including 37 asthmatics and 66 nonasthmatic controls. Both groups underwent analyses for serum periostin, eosinophil levels in the peripheral blood, the fraction of exhaled nitric oxide (FeNO), total serum IgE, urinary leukotriene E(4), and serum cytokines. RESULTS: Higher levels of periostin (p = 0.005), blood eosinophils (p = 0.012), FeNO (p = 0.001), total IgE (p < 0.001), and IL-6 (p ≤ 0.001) were found in the asthmatic patients than the controls. Biomarker analyses by the ROC curve showed an AUC greater than 65%. Periostin (OR: 12,550; 95% CI: 2,498-63,063) and IL-6 (OR: 7,249; 95% CI: 1,737-30,262) revealed to be suitable asthma inflammation biomarkers. Blood eosinophils, FeNO, total IgE, IL-6, TNF, and IFN-g showed correlations with clinical severity characteristics in asthmatic patients. Periostin showed higher values in T2 asthma (p = 0.006) and TNF in non-T2 asthma (p = 0.029). CONCLUSION: The panel of biomarkers proposed for the identification of the inflammatory phenotype of asthmatic patients demonstrated good performance. Periostin proved to be an important biomarker for the identification of T2 asthma. Sociedade Brasileira de Pneumologia e Tisiologia 2023-01-16 /pmc/articles/PMC9970379/ /pubmed/36753209 http://dx.doi.org/10.36416/1806-3756/e20220040 Text en © 2023 Sociedade Brasileira de Pneumologia e Tisiologia https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Original Article
Baldo, Danielle Cristiane
Romaldini, José Gustavo
Pizzichini, Marcia Margaret Menezes
Cançado, José Eduardo D.
Dellavance, Alessandra
Stirbulov, Roberto
Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
title Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
title_full Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
title_fullStr Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
title_full_unstemmed Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
title_short Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
title_sort periostin as an important biomarker of inflammatory phenotype t2 in brazilian asthma patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970379/
https://www.ncbi.nlm.nih.gov/pubmed/36753209
http://dx.doi.org/10.36416/1806-3756/e20220040
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