Cargando…
Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients
OBJECTIVE: The aim of this study was to assess the laboratory performance of periostin associated with a panel of biomarkers to identify the inflammatory phenotype of Brazilian asthma patients. METHODS: We evaluated 103 Brazilian individuals, including 37 asthmatics and 66 nonasthmatic controls. Bot...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Pneumologia e Tisiologia
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970379/ https://www.ncbi.nlm.nih.gov/pubmed/36753209 http://dx.doi.org/10.36416/1806-3756/e20220040 |
_version_ | 1784897903344484352 |
---|---|
author | Baldo, Danielle Cristiane Romaldini, José Gustavo Pizzichini, Marcia Margaret Menezes Cançado, José Eduardo D. Dellavance, Alessandra Stirbulov, Roberto |
author_facet | Baldo, Danielle Cristiane Romaldini, José Gustavo Pizzichini, Marcia Margaret Menezes Cançado, José Eduardo D. Dellavance, Alessandra Stirbulov, Roberto |
author_sort | Baldo, Danielle Cristiane |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to assess the laboratory performance of periostin associated with a panel of biomarkers to identify the inflammatory phenotype of Brazilian asthma patients. METHODS: We evaluated 103 Brazilian individuals, including 37 asthmatics and 66 nonasthmatic controls. Both groups underwent analyses for serum periostin, eosinophil levels in the peripheral blood, the fraction of exhaled nitric oxide (FeNO), total serum IgE, urinary leukotriene E(4), and serum cytokines. RESULTS: Higher levels of periostin (p = 0.005), blood eosinophils (p = 0.012), FeNO (p = 0.001), total IgE (p < 0.001), and IL-6 (p ≤ 0.001) were found in the asthmatic patients than the controls. Biomarker analyses by the ROC curve showed an AUC greater than 65%. Periostin (OR: 12,550; 95% CI: 2,498-63,063) and IL-6 (OR: 7,249; 95% CI: 1,737-30,262) revealed to be suitable asthma inflammation biomarkers. Blood eosinophils, FeNO, total IgE, IL-6, TNF, and IFN-g showed correlations with clinical severity characteristics in asthmatic patients. Periostin showed higher values in T2 asthma (p = 0.006) and TNF in non-T2 asthma (p = 0.029). CONCLUSION: The panel of biomarkers proposed for the identification of the inflammatory phenotype of asthmatic patients demonstrated good performance. Periostin proved to be an important biomarker for the identification of T2 asthma. |
format | Online Article Text |
id | pubmed-9970379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-99703792023-02-28 Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients Baldo, Danielle Cristiane Romaldini, José Gustavo Pizzichini, Marcia Margaret Menezes Cançado, José Eduardo D. Dellavance, Alessandra Stirbulov, Roberto J Bras Pneumol Original Article OBJECTIVE: The aim of this study was to assess the laboratory performance of periostin associated with a panel of biomarkers to identify the inflammatory phenotype of Brazilian asthma patients. METHODS: We evaluated 103 Brazilian individuals, including 37 asthmatics and 66 nonasthmatic controls. Both groups underwent analyses for serum periostin, eosinophil levels in the peripheral blood, the fraction of exhaled nitric oxide (FeNO), total serum IgE, urinary leukotriene E(4), and serum cytokines. RESULTS: Higher levels of periostin (p = 0.005), blood eosinophils (p = 0.012), FeNO (p = 0.001), total IgE (p < 0.001), and IL-6 (p ≤ 0.001) were found in the asthmatic patients than the controls. Biomarker analyses by the ROC curve showed an AUC greater than 65%. Periostin (OR: 12,550; 95% CI: 2,498-63,063) and IL-6 (OR: 7,249; 95% CI: 1,737-30,262) revealed to be suitable asthma inflammation biomarkers. Blood eosinophils, FeNO, total IgE, IL-6, TNF, and IFN-g showed correlations with clinical severity characteristics in asthmatic patients. Periostin showed higher values in T2 asthma (p = 0.006) and TNF in non-T2 asthma (p = 0.029). CONCLUSION: The panel of biomarkers proposed for the identification of the inflammatory phenotype of asthmatic patients demonstrated good performance. Periostin proved to be an important biomarker for the identification of T2 asthma. Sociedade Brasileira de Pneumologia e Tisiologia 2023-01-16 /pmc/articles/PMC9970379/ /pubmed/36753209 http://dx.doi.org/10.36416/1806-3756/e20220040 Text en © 2023 Sociedade Brasileira de Pneumologia e Tisiologia https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Original Article Baldo, Danielle Cristiane Romaldini, José Gustavo Pizzichini, Marcia Margaret Menezes Cançado, José Eduardo D. Dellavance, Alessandra Stirbulov, Roberto Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients |
title | Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients |
title_full | Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients |
title_fullStr | Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients |
title_full_unstemmed | Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients |
title_short | Periostin as an important biomarker of inflammatory phenotype T2 in Brazilian asthma patients |
title_sort | periostin as an important biomarker of inflammatory phenotype t2 in brazilian asthma patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970379/ https://www.ncbi.nlm.nih.gov/pubmed/36753209 http://dx.doi.org/10.36416/1806-3756/e20220040 |
work_keys_str_mv | AT baldodaniellecristiane periostinasanimportantbiomarkerofinflammatoryphenotypet2inbrazilianasthmapatients AT romaldinijosegustavo periostinasanimportantbiomarkerofinflammatoryphenotypet2inbrazilianasthmapatients AT pizzichinimarciamargaretmenezes periostinasanimportantbiomarkerofinflammatoryphenotypet2inbrazilianasthmapatients AT cancadojoseeduardod periostinasanimportantbiomarkerofinflammatoryphenotypet2inbrazilianasthmapatients AT dellavancealessandra periostinasanimportantbiomarkerofinflammatoryphenotypet2inbrazilianasthmapatients AT stirbulovroberto periostinasanimportantbiomarkerofinflammatoryphenotypet2inbrazilianasthmapatients |