Relapsing Polychondritis and Aseptic Meningoencephalitis

We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from...

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Detalles Bibliográficos
Autores principales: Yokota, Kazuhiro, Tachibana, Hideyuki, Miyake, Akifumi, Yamamoto, Toshimasa, Mimura, Toshihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970797/
https://www.ncbi.nlm.nih.gov/pubmed/35831110
http://dx.doi.org/10.2169/internalmedicine.9411-22
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author Yokota, Kazuhiro
Tachibana, Hideyuki
Miyake, Akifumi
Yamamoto, Toshimasa
Mimura, Toshihide
author_facet Yokota, Kazuhiro
Tachibana, Hideyuki
Miyake, Akifumi
Yamamoto, Toshimasa
Mimura, Toshihide
author_sort Yokota, Kazuhiro
collection PubMed
description We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from six months before hospitalization. Methylprednisolone pulse therapy was immediately initiated, followed by administration of PSL at 1 mg/kg/day. Intravenous cyclophosphamide was combined with PSL. After treatment, the patient's cognitive impairment clearly improved. In conclusion, RP rarely causes aseptic meningoencephalitis, highlighting the need for prompt and aggressive immunosuppressive therapy.
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spelling pubmed-99707972023-02-28 Relapsing Polychondritis and Aseptic Meningoencephalitis Yokota, Kazuhiro Tachibana, Hideyuki Miyake, Akifumi Yamamoto, Toshimasa Mimura, Toshihide Intern Med Case Report We herein report a 49-year-old Japanese man with relapsing polychondritis (RP) and aseptic meningoencephalitis. Four years ago, the patient was diagnosed with RP. Prednisolone (PSL) was started at 30 mg/day, and the symptoms promptly disappeared. However, cognitive impairment gradually appeared from six months before hospitalization. Methylprednisolone pulse therapy was immediately initiated, followed by administration of PSL at 1 mg/kg/day. Intravenous cyclophosphamide was combined with PSL. After treatment, the patient's cognitive impairment clearly improved. In conclusion, RP rarely causes aseptic meningoencephalitis, highlighting the need for prompt and aggressive immunosuppressive therapy. The Japanese Society of Internal Medicine 2022-07-14 2023-02-01 /pmc/articles/PMC9970797/ /pubmed/35831110 http://dx.doi.org/10.2169/internalmedicine.9411-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yokota, Kazuhiro
Tachibana, Hideyuki
Miyake, Akifumi
Yamamoto, Toshimasa
Mimura, Toshihide
Relapsing Polychondritis and Aseptic Meningoencephalitis
title Relapsing Polychondritis and Aseptic Meningoencephalitis
title_full Relapsing Polychondritis and Aseptic Meningoencephalitis
title_fullStr Relapsing Polychondritis and Aseptic Meningoencephalitis
title_full_unstemmed Relapsing Polychondritis and Aseptic Meningoencephalitis
title_short Relapsing Polychondritis and Aseptic Meningoencephalitis
title_sort relapsing polychondritis and aseptic meningoencephalitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970797/
https://www.ncbi.nlm.nih.gov/pubmed/35831110
http://dx.doi.org/10.2169/internalmedicine.9411-22
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