Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib

Many patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in the patients of PVRL with relapsed or refractory CNS remains extremely poor. We herein report a patient with refractory PVRL who had...

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Autores principales: Iizuka-Honma, Hiroko, Takizawa, Haruko, Mitsumori, Toru, Okura, Hidehiro, Ishii, Hisato, Noguchi, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970806/
https://www.ncbi.nlm.nih.gov/pubmed/35793963
http://dx.doi.org/10.2169/internalmedicine.9591-22
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author Iizuka-Honma, Hiroko
Takizawa, Haruko
Mitsumori, Toru
Okura, Hidehiro
Ishii, Hisato
Noguchi, Masaaki
author_facet Iizuka-Honma, Hiroko
Takizawa, Haruko
Mitsumori, Toru
Okura, Hidehiro
Ishii, Hisato
Noguchi, Masaaki
author_sort Iizuka-Honma, Hiroko
collection PubMed
description Many patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in the patients of PVRL with relapsed or refractory CNS remains extremely poor. We herein report a patient with refractory PVRL who had recurrence in the spinal cord despite receiving high-dose methotrexate-based chemotherapy and whole-brain radiotherapy. The patient surprisingly responded to tirabrutinib temporarily. We believe that this case suggests the utility of this new target therapy.
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spelling pubmed-99708062023-02-28 Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib Iizuka-Honma, Hiroko Takizawa, Haruko Mitsumori, Toru Okura, Hidehiro Ishii, Hisato Noguchi, Masaaki Intern Med Case Report Many patients with primary vitreoretinal lymphoma (PVRL) exhibit central nervous system (CNS) involvement either at the diagnosis or during follow-up. The prognosis in the patients of PVRL with relapsed or refractory CNS remains extremely poor. We herein report a patient with refractory PVRL who had recurrence in the spinal cord despite receiving high-dose methotrexate-based chemotherapy and whole-brain radiotherapy. The patient surprisingly responded to tirabrutinib temporarily. We believe that this case suggests the utility of this new target therapy. The Japanese Society of Internal Medicine 2022-07-05 2023-02-01 /pmc/articles/PMC9970806/ /pubmed/35793963 http://dx.doi.org/10.2169/internalmedicine.9591-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Iizuka-Honma, Hiroko
Takizawa, Haruko
Mitsumori, Toru
Okura, Hidehiro
Ishii, Hisato
Noguchi, Masaaki
Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib
title Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib
title_full Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib
title_fullStr Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib
title_full_unstemmed Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib
title_short Refractory Primary Vitreoretinal Lymphoma Involving the Spinal Cord with a Temporary Complete Response to Tirabrutinib
title_sort refractory primary vitreoretinal lymphoma involving the spinal cord with a temporary complete response to tirabrutinib
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970806/
https://www.ncbi.nlm.nih.gov/pubmed/35793963
http://dx.doi.org/10.2169/internalmedicine.9591-22
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