Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review

We herein report a rare case of spinal cord compression due to epidural involvement of acute myeloid leukemia (AML). A 14-year-old boy presented with a 7-day history of back pain, paraplegia and hypoesthesia. Contrast-enhanced computed tomography revealed an epidural mass. Emergency laminectomy and...

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Autores principales: Fujikawa, Tomoko, Kishimoto, Kenji, Inoue, Shotaro, Nishimura, Akihiro, Tojo, Ryunosuke, Uemura, Suguru, Nakamura, Sayaka, Saito, Atsuro, Kozaki, Aiko, Ishida, Toshiaki, Mori, Takeshi, Higashino, Masashi, Koyama, Junji, Kawamura, Atsufumi, Hasegawa, Daiichiro, Kosaka, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970809/
https://www.ncbi.nlm.nih.gov/pubmed/35793962
http://dx.doi.org/10.2169/internalmedicine.9580-22
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author Fujikawa, Tomoko
Kishimoto, Kenji
Inoue, Shotaro
Nishimura, Akihiro
Tojo, Ryunosuke
Uemura, Suguru
Nakamura, Sayaka
Saito, Atsuro
Kozaki, Aiko
Ishida, Toshiaki
Mori, Takeshi
Higashino, Masashi
Koyama, Junji
Kawamura, Atsufumi
Hasegawa, Daiichiro
Kosaka, Yoshiyuki
author_facet Fujikawa, Tomoko
Kishimoto, Kenji
Inoue, Shotaro
Nishimura, Akihiro
Tojo, Ryunosuke
Uemura, Suguru
Nakamura, Sayaka
Saito, Atsuro
Kozaki, Aiko
Ishida, Toshiaki
Mori, Takeshi
Higashino, Masashi
Koyama, Junji
Kawamura, Atsufumi
Hasegawa, Daiichiro
Kosaka, Yoshiyuki
author_sort Fujikawa, Tomoko
collection PubMed
description We herein report a rare case of spinal cord compression due to epidural involvement of acute myeloid leukemia (AML). A 14-year-old boy presented with a 7-day history of back pain, paraplegia and hypoesthesia. Contrast-enhanced computed tomography revealed an epidural mass. Emergency laminectomy and resection of the mass were performed. Histopathologically, the resected mass was comparable to an extramedullary mass of AML. Chemotherapy was initiated, and complete remission was achieved. Neurological sequelae remained after the treatment. Based on the present and previous reports, spinal cord compression from epidural AML involvement may progress rapidly.
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spelling pubmed-99708092023-02-28 Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review Fujikawa, Tomoko Kishimoto, Kenji Inoue, Shotaro Nishimura, Akihiro Tojo, Ryunosuke Uemura, Suguru Nakamura, Sayaka Saito, Atsuro Kozaki, Aiko Ishida, Toshiaki Mori, Takeshi Higashino, Masashi Koyama, Junji Kawamura, Atsufumi Hasegawa, Daiichiro Kosaka, Yoshiyuki Intern Med Case Report We herein report a rare case of spinal cord compression due to epidural involvement of acute myeloid leukemia (AML). A 14-year-old boy presented with a 7-day history of back pain, paraplegia and hypoesthesia. Contrast-enhanced computed tomography revealed an epidural mass. Emergency laminectomy and resection of the mass were performed. Histopathologically, the resected mass was comparable to an extramedullary mass of AML. Chemotherapy was initiated, and complete remission was achieved. Neurological sequelae remained after the treatment. Based on the present and previous reports, spinal cord compression from epidural AML involvement may progress rapidly. The Japanese Society of Internal Medicine 2022-07-05 2023-02-01 /pmc/articles/PMC9970809/ /pubmed/35793962 http://dx.doi.org/10.2169/internalmedicine.9580-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Fujikawa, Tomoko
Kishimoto, Kenji
Inoue, Shotaro
Nishimura, Akihiro
Tojo, Ryunosuke
Uemura, Suguru
Nakamura, Sayaka
Saito, Atsuro
Kozaki, Aiko
Ishida, Toshiaki
Mori, Takeshi
Higashino, Masashi
Koyama, Junji
Kawamura, Atsufumi
Hasegawa, Daiichiro
Kosaka, Yoshiyuki
Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
title Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
title_full Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
title_fullStr Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
title_full_unstemmed Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
title_short Epidural Spinal Cord Compression as the Presenting Manifestation of Acute Myeloid Leukemia: A Case Report and Literature Review
title_sort epidural spinal cord compression as the presenting manifestation of acute myeloid leukemia: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970809/
https://www.ncbi.nlm.nih.gov/pubmed/35793962
http://dx.doi.org/10.2169/internalmedicine.9580-22
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