Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer

A 71-year-old man was admitted for left-sided chest pain. He had a history of diabetes, treatment with epidermal growth factor receptor-tyrosine kinase inhibitor for advanced non-small-cell lung cancer, and corticosteroid treatment for underlying lung diseases. Chest computed tomography showed conso...

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Autores principales: Hirama, Ryutaro, Kono, Masato, Kobayashi, Takeshi, Oshima, Yuiko, Takeda, Kenichiro, Miyashita, Koichi, Miwa, Hideki, Tsutsumi, Akari, Miki, Yoshihiro, Hashimoto, Dai, Otsuki, Yoshiro, Nakamura, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970813/
https://www.ncbi.nlm.nih.gov/pubmed/35732455
http://dx.doi.org/10.2169/internalmedicine.9714-22
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author Hirama, Ryutaro
Kono, Masato
Kobayashi, Takeshi
Oshima, Yuiko
Takeda, Kenichiro
Miyashita, Koichi
Miwa, Hideki
Tsutsumi, Akari
Miki, Yoshihiro
Hashimoto, Dai
Otsuki, Yoshiro
Nakamura, Hidenori
author_facet Hirama, Ryutaro
Kono, Masato
Kobayashi, Takeshi
Oshima, Yuiko
Takeda, Kenichiro
Miyashita, Koichi
Miwa, Hideki
Tsutsumi, Akari
Miki, Yoshihiro
Hashimoto, Dai
Otsuki, Yoshiro
Nakamura, Hidenori
author_sort Hirama, Ryutaro
collection PubMed
description A 71-year-old man was admitted for left-sided chest pain. He had a history of diabetes, treatment with epidermal growth factor receptor-tyrosine kinase inhibitor for advanced non-small-cell lung cancer, and corticosteroid treatment for underlying lung diseases. Chest computed tomography showed consolidations in the bilateral lower lobes, and Aspergillus fumigatus was detected by bronchoscopy. Invasive pulmonary aspergillosis was suspected, and antifungal therapy with voriconazole was initiated; however, the patient passed away suddenly. Autopsy revealed disseminated Aspergillus infection and intra-abdominal hemorrhage due to the rupture of a splenic vein aneurysm caused by Aspergillus necrotizing vasculitis, which was considered the cause of death.
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spelling pubmed-99708132023-02-28 Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer Hirama, Ryutaro Kono, Masato Kobayashi, Takeshi Oshima, Yuiko Takeda, Kenichiro Miyashita, Koichi Miwa, Hideki Tsutsumi, Akari Miki, Yoshihiro Hashimoto, Dai Otsuki, Yoshiro Nakamura, Hidenori Intern Med Case Report A 71-year-old man was admitted for left-sided chest pain. He had a history of diabetes, treatment with epidermal growth factor receptor-tyrosine kinase inhibitor for advanced non-small-cell lung cancer, and corticosteroid treatment for underlying lung diseases. Chest computed tomography showed consolidations in the bilateral lower lobes, and Aspergillus fumigatus was detected by bronchoscopy. Invasive pulmonary aspergillosis was suspected, and antifungal therapy with voriconazole was initiated; however, the patient passed away suddenly. Autopsy revealed disseminated Aspergillus infection and intra-abdominal hemorrhage due to the rupture of a splenic vein aneurysm caused by Aspergillus necrotizing vasculitis, which was considered the cause of death. The Japanese Society of Internal Medicine 2022-06-21 2023-02-01 /pmc/articles/PMC9970813/ /pubmed/35732455 http://dx.doi.org/10.2169/internalmedicine.9714-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hirama, Ryutaro
Kono, Masato
Kobayashi, Takeshi
Oshima, Yuiko
Takeda, Kenichiro
Miyashita, Koichi
Miwa, Hideki
Tsutsumi, Akari
Miki, Yoshihiro
Hashimoto, Dai
Otsuki, Yoshiro
Nakamura, Hidenori
Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer
title Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer
title_full Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer
title_fullStr Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer
title_full_unstemmed Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer
title_short Intra-abdominal Hemorrhage Due to Splenic Vein Aneurysm Rupture Caused by Invasive Aspergillosis during Treatment for Advanced Non-small-cell Lung Cancer
title_sort intra-abdominal hemorrhage due to splenic vein aneurysm rupture caused by invasive aspergillosis during treatment for advanced non-small-cell lung cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970813/
https://www.ncbi.nlm.nih.gov/pubmed/35732455
http://dx.doi.org/10.2169/internalmedicine.9714-22
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