Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness

The accumulation of acidic metabolic waste products within the tumor microenvironment inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains unclear how an acidic environment affects T cell metabolism and differentiation. Here we show that prolonged exposure to aci...

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Detalles Bibliográficos
Autores principales: Cheng, Hongcheng, Qiu, Yajing, Xu, Yue, Chen, Li, Ma, Kaili, Tao, Mengyuan, Frankiw, Luke, Yin, Hongli, Xie, Ermei, Pan, Xiaoli, Du, Jing, Wang, Zhe, Zhu, Wenjie, Chen, Lu, Zhang, Lianjun, Li, Guideng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970874/
https://www.ncbi.nlm.nih.gov/pubmed/36717749
http://dx.doi.org/10.1038/s42255-022-00730-6

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