Fucosylation of HLA-DRB1 regulates CD4(+) T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy

Immunotherapy efficacy is limited in melanoma, and combinations of immunotherapies with other modalities have yielded limited improvements but also adverse events requiring cessation of treatment. In addition to ineffective patient stratification, efficacy is impaired by paucity of intratumoral immu...

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Detalles Bibliográficos
Autores principales: Lester, Daniel K., Burton, Chase, Gardner, Alycia, Innamarato, Patrick, Kodumudi, Krithika, Liu, Qian, Adhikari, Emma, Ming, Qianqian, Williamson, Daniel B., Frederick, Dennie T., Sharova, Tatyana, White, Michael G., Markowitz, Joseph, Cao, Biwei, Nguyen, Jonathan, Johnson, Joseph, Beatty, Matthew, Mockabee-Macias, Andrea, Mercurio, Matthew, Watson, Gregory, Chen, Pei-Ling, McCarthy, Susan, MoranSegura, Carlos, Messina, Jane, Thomas, Kerry L., Darville, Lancia, Izumi, Victoria, Koomen, John M., Pilon-Thomas, Shari A., Ruffell, Brian, Luca, Vincent C., Haltiwanger, Robert S., Wang, Xuefeng, Wargo, Jennifer A., Boland, Genevieve M., Lau, Eric K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970875/
https://www.ncbi.nlm.nih.gov/pubmed/36690875
http://dx.doi.org/10.1038/s43018-022-00506-7

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