Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43

A number of synthetic hydroxy-xanthones related to isolates from the plant genus Swertia (family Gentianaceae) were prepared and their antiviral activity assessed against human coronavirus OC43. Overall, the results of the initial screening of the test compounds in BHK-21 cell lines show promising b...

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Autores principales: Dean, Bethanie, Cooper, Gemma, Shivkumar, Maitreyi, Snape, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970925/
https://www.ncbi.nlm.nih.gov/pubmed/36863494
http://dx.doi.org/10.1016/j.bmcl.2023.129211
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author Dean, Bethanie
Cooper, Gemma
Shivkumar, Maitreyi
Snape, Timothy J.
author_facet Dean, Bethanie
Cooper, Gemma
Shivkumar, Maitreyi
Snape, Timothy J.
author_sort Dean, Bethanie
collection PubMed
description A number of synthetic hydroxy-xanthones related to isolates from the plant genus Swertia (family Gentianaceae) were prepared and their antiviral activity assessed against human coronavirus OC43. Overall, the results of the initial screening of the test compounds in BHK-21 cell lines show promising biological activity, with a significant reduction in viral infectivity (p ≤ 0.05). In general, the addition of functionality around the xanthone core increases the biological activity of the compounds compared to xanthone itself. More detailed studies are needed to determine mechanism of action, but favourable property predictions make them interesting lead compounds for further development as potential treatments for coronavirus infections.
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spelling pubmed-99709252023-02-28 Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43 Dean, Bethanie Cooper, Gemma Shivkumar, Maitreyi Snape, Timothy J. Bioorg Med Chem Lett Article A number of synthetic hydroxy-xanthones related to isolates from the plant genus Swertia (family Gentianaceae) were prepared and their antiviral activity assessed against human coronavirus OC43. Overall, the results of the initial screening of the test compounds in BHK-21 cell lines show promising biological activity, with a significant reduction in viral infectivity (p ≤ 0.05). In general, the addition of functionality around the xanthone core increases the biological activity of the compounds compared to xanthone itself. More detailed studies are needed to determine mechanism of action, but favourable property predictions make them interesting lead compounds for further development as potential treatments for coronavirus infections. The Authors. Published by Elsevier Ltd. 2023-03-15 2023-02-28 /pmc/articles/PMC9970925/ /pubmed/36863494 http://dx.doi.org/10.1016/j.bmcl.2023.129211 Text en © 2023 The Authors. Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Dean, Bethanie
Cooper, Gemma
Shivkumar, Maitreyi
Snape, Timothy J.
Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43
title Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43
title_full Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43
title_fullStr Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43
title_full_unstemmed Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43
title_short Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43
title_sort hydroxy-xanthones as promising antiviral agents: synthesis and biological evaluation against human coronavirus oc43
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970925/
https://www.ncbi.nlm.nih.gov/pubmed/36863494
http://dx.doi.org/10.1016/j.bmcl.2023.129211
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