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Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study
OBJECTIVE: Persistent pain and loss of shoulder function are common adverse effects to breast cancer treatment, but the extent of these issues in comparison with healthy controls is unclear for survivors beyond 1.5 years after treatment. The purpose of this study was to benchmark differences in pres...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970942/ https://www.ncbi.nlm.nih.gov/pubmed/33495914 http://dx.doi.org/10.1007/s11764-021-00995-y |
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author | Rasmussen, G. H. F. Madeleine, P. Arroyo-Morales, M. Voigt, M. Kristiansen, M. |
author_facet | Rasmussen, G. H. F. Madeleine, P. Arroyo-Morales, M. Voigt, M. Kristiansen, M. |
author_sort | Rasmussen, G. H. F. |
collection | PubMed |
description | OBJECTIVE: Persistent pain and loss of shoulder function are common adverse effects to breast cancer treatment, but the extent of these issues in comparison with healthy controls is unclear for survivors beyond 1.5 years after treatment. The purpose of this study was to benchmark differences in pressure pain thresholds (PPT), maximal isokinetic muscle strength (MIMS), and active range of motion (ROM) of females with persistent pain ≥1.5 years after breast cancer treatment (BCS) compared with pain-free matched controls (CON), and examine the presence of movement-evoked pain (MEP) during assessment of MIMS. METHODS: The PPTs of 18 locations were assessed using a pressure algometer and a numeric rating scale was used to assess intensity of MEP. Active ROM and MIMS were measured using a universal goniometer and an isokinetic dynamometer, respectively. RESULTS: A two-way analysis of variance revealed that PPTs across all locations, MIMS for horizontal shoulder extension/flexion and shoulder adduction, active ROM for shoulder flexion, horizontal shoulder extension, shoulder abduction, and external shoulder rotation were significantly lower for BCS compared with CON (P < 0.05). MEP was significantly higher for BCS and MEP intensity had a significant, negative correlation with PPTs (P < 0.01). DISCUSSION/CONCLUSION: BCS with persistent pain ≥1.5 years after treatment demonstrates widespread reductions in PPTs and movement-specific reductions in MIMS and active ROM of the affected shoulder, along with MEP during physical performance assessment. IMPLICATIONS FOR CANCER SURVIVORS: BCS with persistent pain ≥1.5 years after treatment shows signs of central sensitization and may benefit from individualized rehabilitation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11764-021-00995-y. |
format | Online Article Text |
id | pubmed-9970942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-99709422023-03-01 Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study Rasmussen, G. H. F. Madeleine, P. Arroyo-Morales, M. Voigt, M. Kristiansen, M. J Cancer Surviv Article OBJECTIVE: Persistent pain and loss of shoulder function are common adverse effects to breast cancer treatment, but the extent of these issues in comparison with healthy controls is unclear for survivors beyond 1.5 years after treatment. The purpose of this study was to benchmark differences in pressure pain thresholds (PPT), maximal isokinetic muscle strength (MIMS), and active range of motion (ROM) of females with persistent pain ≥1.5 years after breast cancer treatment (BCS) compared with pain-free matched controls (CON), and examine the presence of movement-evoked pain (MEP) during assessment of MIMS. METHODS: The PPTs of 18 locations were assessed using a pressure algometer and a numeric rating scale was used to assess intensity of MEP. Active ROM and MIMS were measured using a universal goniometer and an isokinetic dynamometer, respectively. RESULTS: A two-way analysis of variance revealed that PPTs across all locations, MIMS for horizontal shoulder extension/flexion and shoulder adduction, active ROM for shoulder flexion, horizontal shoulder extension, shoulder abduction, and external shoulder rotation were significantly lower for BCS compared with CON (P < 0.05). MEP was significantly higher for BCS and MEP intensity had a significant, negative correlation with PPTs (P < 0.01). DISCUSSION/CONCLUSION: BCS with persistent pain ≥1.5 years after treatment demonstrates widespread reductions in PPTs and movement-specific reductions in MIMS and active ROM of the affected shoulder, along with MEP during physical performance assessment. IMPLICATIONS FOR CANCER SURVIVORS: BCS with persistent pain ≥1.5 years after treatment shows signs of central sensitization and may benefit from individualized rehabilitation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11764-021-00995-y. Springer US 2021-01-26 2023 /pmc/articles/PMC9970942/ /pubmed/33495914 http://dx.doi.org/10.1007/s11764-021-00995-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rasmussen, G. H. F. Madeleine, P. Arroyo-Morales, M. Voigt, M. Kristiansen, M. Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
title | Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
title_full | Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
title_fullStr | Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
title_full_unstemmed | Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
title_short | Pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
title_sort | pain sensitivity and shoulder function among breast cancer survivors compared to matched controls: a case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970942/ https://www.ncbi.nlm.nih.gov/pubmed/33495914 http://dx.doi.org/10.1007/s11764-021-00995-y |
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