Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming

Dysregulation of Th17 and Treg cells contributes to the pathophysiology of many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits Th17 cell differentiation and promotes Treg cell differentiation by orchestrating metabolic and epigenetic reprogramming. Mech...

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Detalles Bibliográficos
Autores principales: Aso, Kuniyuki, Kono, Michihito, Kanda, Masatoshi, Kudo, Yuki, Sakiyama, Kodai, Hisada, Ryo, Karino, Kohei, Ueda, Yusho, Nakazawa, Daigo, Fujieda, Yuichiro, Kato, Masaru, Amengual, Olga, Atsumi, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970976/
https://www.ncbi.nlm.nih.gov/pubmed/36849508
http://dx.doi.org/10.1038/s41467-023-36594-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970976/
https://www.ncbi.nlm.nih.gov/pubmed/36849508
http://dx.doi.org/10.1038/s41467-023-36594-x

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