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KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970984/ https://www.ncbi.nlm.nih.gov/pubmed/36849520 http://dx.doi.org/10.1038/s41419-023-05582-w |
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author | Qiu, Bingquan Li, Shen Li, Meiting Wang, Shuo Mu, Guanqun Chen, Keyu Wang, Meng Zhu, Wei-guo Wang, Weibin Wang, Jiadong Li, Ziyu Yang, Jichun Yang, Yang |
author_facet | Qiu, Bingquan Li, Shen Li, Meiting Wang, Shuo Mu, Guanqun Chen, Keyu Wang, Meng Zhu, Wei-guo Wang, Weibin Wang, Jiadong Li, Ziyu Yang, Jichun Yang, Yang |
author_sort | Qiu, Bingquan |
collection | PubMed |
description | Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect of KAT8 on lipolysis is unclear. Here, we report a novel mechanism of KAT8 on lipolysis involving in its acetylation by general control non-repressed protein 5 (GCN5) and its deacetylation by Sirtuin 6 (SIRT6). KAT8 acetylation at K168/175 residues attenuates the binding activity of KAT8 and inhibits the recruitment of RNA pol II to the promoter region of the lipolysis-related genes adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), subsequently down-regulating lipolysis to affect the invasive and migratory potential of colorectal cancer cells. Our findings uncover a novel mechanism that KAT8 acetylation-controlled lipolysis affects invasive and migratory potential in colorectal cancer cells. |
format | Online Article Text |
id | pubmed-9970984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99709842023-03-01 KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells Qiu, Bingquan Li, Shen Li, Meiting Wang, Shuo Mu, Guanqun Chen, Keyu Wang, Meng Zhu, Wei-guo Wang, Weibin Wang, Jiadong Li, Ziyu Yang, Jichun Yang, Yang Cell Death Dis Article Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect of KAT8 on lipolysis is unclear. Here, we report a novel mechanism of KAT8 on lipolysis involving in its acetylation by general control non-repressed protein 5 (GCN5) and its deacetylation by Sirtuin 6 (SIRT6). KAT8 acetylation at K168/175 residues attenuates the binding activity of KAT8 and inhibits the recruitment of RNA pol II to the promoter region of the lipolysis-related genes adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), subsequently down-regulating lipolysis to affect the invasive and migratory potential of colorectal cancer cells. Our findings uncover a novel mechanism that KAT8 acetylation-controlled lipolysis affects invasive and migratory potential in colorectal cancer cells. Nature Publishing Group UK 2023-02-27 /pmc/articles/PMC9970984/ /pubmed/36849520 http://dx.doi.org/10.1038/s41419-023-05582-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Qiu, Bingquan Li, Shen Li, Meiting Wang, Shuo Mu, Guanqun Chen, Keyu Wang, Meng Zhu, Wei-guo Wang, Weibin Wang, Jiadong Li, Ziyu Yang, Jichun Yang, Yang KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
title | KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
title_full | KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
title_fullStr | KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
title_full_unstemmed | KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
title_short | KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
title_sort | kat8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970984/ https://www.ncbi.nlm.nih.gov/pubmed/36849520 http://dx.doi.org/10.1038/s41419-023-05582-w |
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