Cargando…

KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells

Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Bingquan, Li, Shen, Li, Meiting, Wang, Shuo, Mu, Guanqun, Chen, Keyu, Wang, Meng, Zhu, Wei-guo, Wang, Weibin, Wang, Jiadong, Li, Ziyu, Yang, Jichun, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970984/
https://www.ncbi.nlm.nih.gov/pubmed/36849520
http://dx.doi.org/10.1038/s41419-023-05582-w
_version_ 1784898012110127104
author Qiu, Bingquan
Li, Shen
Li, Meiting
Wang, Shuo
Mu, Guanqun
Chen, Keyu
Wang, Meng
Zhu, Wei-guo
Wang, Weibin
Wang, Jiadong
Li, Ziyu
Yang, Jichun
Yang, Yang
author_facet Qiu, Bingquan
Li, Shen
Li, Meiting
Wang, Shuo
Mu, Guanqun
Chen, Keyu
Wang, Meng
Zhu, Wei-guo
Wang, Weibin
Wang, Jiadong
Li, Ziyu
Yang, Jichun
Yang, Yang
author_sort Qiu, Bingquan
collection PubMed
description Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect of KAT8 on lipolysis is unclear. Here, we report a novel mechanism of KAT8 on lipolysis involving in its acetylation by general control non-repressed protein 5 (GCN5) and its deacetylation by Sirtuin 6 (SIRT6). KAT8 acetylation at K168/175 residues attenuates the binding activity of KAT8 and inhibits the recruitment of RNA pol II to the promoter region of the lipolysis-related genes adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), subsequently down-regulating lipolysis to affect the invasive and migratory potential of colorectal cancer cells. Our findings uncover a novel mechanism that KAT8 acetylation-controlled lipolysis affects invasive and migratory potential in colorectal cancer cells.
format Online
Article
Text
id pubmed-9970984
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-99709842023-03-01 KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells Qiu, Bingquan Li, Shen Li, Meiting Wang, Shuo Mu, Guanqun Chen, Keyu Wang, Meng Zhu, Wei-guo Wang, Weibin Wang, Jiadong Li, Ziyu Yang, Jichun Yang, Yang Cell Death Dis Article Epigenetic mechanisms involved in gene expression play an essential role in various cellular processes, including lipid metabolism. Lysine acetyltransferase 8 (KAT8), a histone acetyltransferase, has been reported to mediate de novo lipogenesis by acetylating fatty acid synthase. However, the effect of KAT8 on lipolysis is unclear. Here, we report a novel mechanism of KAT8 on lipolysis involving in its acetylation by general control non-repressed protein 5 (GCN5) and its deacetylation by Sirtuin 6 (SIRT6). KAT8 acetylation at K168/175 residues attenuates the binding activity of KAT8 and inhibits the recruitment of RNA pol II to the promoter region of the lipolysis-related genes adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL), subsequently down-regulating lipolysis to affect the invasive and migratory potential of colorectal cancer cells. Our findings uncover a novel mechanism that KAT8 acetylation-controlled lipolysis affects invasive and migratory potential in colorectal cancer cells. Nature Publishing Group UK 2023-02-27 /pmc/articles/PMC9970984/ /pubmed/36849520 http://dx.doi.org/10.1038/s41419-023-05582-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qiu, Bingquan
Li, Shen
Li, Meiting
Wang, Shuo
Mu, Guanqun
Chen, Keyu
Wang, Meng
Zhu, Wei-guo
Wang, Weibin
Wang, Jiadong
Li, Ziyu
Yang, Jichun
Yang, Yang
KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
title KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
title_full KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
title_fullStr KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
title_full_unstemmed KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
title_short KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
title_sort kat8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9970984/
https://www.ncbi.nlm.nih.gov/pubmed/36849520
http://dx.doi.org/10.1038/s41419-023-05582-w
work_keys_str_mv AT qiubingquan kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT lishen kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT limeiting kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT wangshuo kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT muguanqun kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT chenkeyu kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT wangmeng kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT zhuweiguo kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT wangweibin kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT wangjiadong kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT liziyu kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT yangjichun kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells
AT yangyang kat8acetylationcontrolledlipolysisaffectstheinvasiveandmigratorypotentialofcolorectalcancercells