Inclusion body myositis: from genetics to clinical trials

Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose a...

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Autores principales: Nagy, Sara, Khan, Alaa, Machado, Pedro M., Houlden, Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Neurological Update
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971047/
https://www.ncbi.nlm.nih.gov/pubmed/36399165
http://dx.doi.org/10.1007/s00415-022-11459-3
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author Nagy, Sara
Khan, Alaa
Machado, Pedro M.
Houlden, Henry
author_facet Nagy, Sara
Khan, Alaa
Machado, Pedro M.
Houlden, Henry
author_sort Nagy, Sara
collection PubMed
description Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited. This review gives an overview of the disease and focuses on the current genetic knowledge and potential therapeutic implications.
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spelling pubmed-99710472023-03-01 Inclusion body myositis: from genetics to clinical trials Nagy, Sara Khan, Alaa Machado, Pedro M. Houlden, Henry J Neurol Neurological Update Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited. This review gives an overview of the disease and focuses on the current genetic knowledge and potential therapeutic implications. Springer Berlin Heidelberg 2022-11-18 2023 /pmc/articles/PMC9971047/ /pubmed/36399165 http://dx.doi.org/10.1007/s00415-022-11459-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Neurological Update
Nagy, Sara
Khan, Alaa
Machado, Pedro M.
Houlden, Henry
Inclusion body myositis: from genetics to clinical trials
title Inclusion body myositis: from genetics to clinical trials
title_full Inclusion body myositis: from genetics to clinical trials
title_fullStr Inclusion body myositis: from genetics to clinical trials
title_full_unstemmed Inclusion body myositis: from genetics to clinical trials
title_short Inclusion body myositis: from genetics to clinical trials
title_sort inclusion body myositis: from genetics to clinical trials
topic Neurological Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971047/
https://www.ncbi.nlm.nih.gov/pubmed/36399165
http://dx.doi.org/10.1007/s00415-022-11459-3
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AT khanalaa inclusionbodymyositisfromgeneticstoclinicaltrials
AT machadopedrom inclusionbodymyositisfromgeneticstoclinicaltrials
AT houldenhenry inclusionbodymyositisfromgeneticstoclinicaltrials

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