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Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis

BACKGROUND: Complete recovery after adequately treated neuroborreliosis is common, but studies report that some patients experience persistent symptoms like self-reported cognitive problems and fatigue. Persisting symptoms are often termed post-Lyme disease syndrome, of which etiology is not clearly...

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Autores principales: Andreassen, Silje, Lindland, Elisabeth Margrete Stokke, Beyer, Mona Kristiansen, Solheim, Anne Marit, Ljøstad, Unn, Mygland, Åse, Lorentzen, Åslaug Rudjord, Reiso, Harald, Bjuland, Knut Jørgen, Pripp, Are Hugo, Harbo, Hanne Flinstad, Løhaugen, Gro Christine Christensen, Eikeland, Randi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971095/
https://www.ncbi.nlm.nih.gov/pubmed/36380166
http://dx.doi.org/10.1007/s00415-022-11463-7
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author Andreassen, Silje
Lindland, Elisabeth Margrete Stokke
Beyer, Mona Kristiansen
Solheim, Anne Marit
Ljøstad, Unn
Mygland, Åse
Lorentzen, Åslaug Rudjord
Reiso, Harald
Bjuland, Knut Jørgen
Pripp, Are Hugo
Harbo, Hanne Flinstad
Løhaugen, Gro Christine Christensen
Eikeland, Randi
author_facet Andreassen, Silje
Lindland, Elisabeth Margrete Stokke
Beyer, Mona Kristiansen
Solheim, Anne Marit
Ljøstad, Unn
Mygland, Åse
Lorentzen, Åslaug Rudjord
Reiso, Harald
Bjuland, Knut Jørgen
Pripp, Are Hugo
Harbo, Hanne Flinstad
Løhaugen, Gro Christine Christensen
Eikeland, Randi
author_sort Andreassen, Silje
collection PubMed
description BACKGROUND: Complete recovery after adequately treated neuroborreliosis is common, but studies report that some patients experience persistent symptoms like self-reported cognitive problems and fatigue. Persisting symptoms are often termed post-Lyme disease syndrome, of which etiology is not clearly understood. The aim of this study was to investigate cognitive function, possible structural changes in brain regions and level of fatigue. We have not found previous studies on neuroborreliosis that use standardized neuropsychological tests and MRI with advanced image processing to investigate if there are subtle regional changes in cortical thickness and brain volumes after treatment. METHODS: We examined 68 patients treated for neuroborreliosis 6 months earlier and 66 healthy controls, with a comprehensive neuropsychological test protocol, quantitative structural MRI analysis of the brain and Fatigue Severity Scale. RESULTS: We found no differences between the groups in either cognitive function, cortical thickness or brain volumes. The patients had higher score on Fatigue Severity Scale 3.8 vs. 2.9 (p = 0.001), and more patients (25.4%) than controls (5%) had severe fatigue (p = 0.002), but neither mean score nor proportion of patients with severe fatigue differed from findings in the general Norwegian population. CONCLUSION: The prognosis regarding cognitive function, brain MRI findings and fatigue after adequately treated neuroborreliosis is favorable.
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spelling pubmed-99710952023-03-01 Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis Andreassen, Silje Lindland, Elisabeth Margrete Stokke Beyer, Mona Kristiansen Solheim, Anne Marit Ljøstad, Unn Mygland, Åse Lorentzen, Åslaug Rudjord Reiso, Harald Bjuland, Knut Jørgen Pripp, Are Hugo Harbo, Hanne Flinstad Løhaugen, Gro Christine Christensen Eikeland, Randi J Neurol Original Communication BACKGROUND: Complete recovery after adequately treated neuroborreliosis is common, but studies report that some patients experience persistent symptoms like self-reported cognitive problems and fatigue. Persisting symptoms are often termed post-Lyme disease syndrome, of which etiology is not clearly understood. The aim of this study was to investigate cognitive function, possible structural changes in brain regions and level of fatigue. We have not found previous studies on neuroborreliosis that use standardized neuropsychological tests and MRI with advanced image processing to investigate if there are subtle regional changes in cortical thickness and brain volumes after treatment. METHODS: We examined 68 patients treated for neuroborreliosis 6 months earlier and 66 healthy controls, with a comprehensive neuropsychological test protocol, quantitative structural MRI analysis of the brain and Fatigue Severity Scale. RESULTS: We found no differences between the groups in either cognitive function, cortical thickness or brain volumes. The patients had higher score on Fatigue Severity Scale 3.8 vs. 2.9 (p = 0.001), and more patients (25.4%) than controls (5%) had severe fatigue (p = 0.002), but neither mean score nor proportion of patients with severe fatigue differed from findings in the general Norwegian population. CONCLUSION: The prognosis regarding cognitive function, brain MRI findings and fatigue after adequately treated neuroborreliosis is favorable. Springer Berlin Heidelberg 2022-11-15 2023 /pmc/articles/PMC9971095/ /pubmed/36380166 http://dx.doi.org/10.1007/s00415-022-11463-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Communication
Andreassen, Silje
Lindland, Elisabeth Margrete Stokke
Beyer, Mona Kristiansen
Solheim, Anne Marit
Ljøstad, Unn
Mygland, Åse
Lorentzen, Åslaug Rudjord
Reiso, Harald
Bjuland, Knut Jørgen
Pripp, Are Hugo
Harbo, Hanne Flinstad
Løhaugen, Gro Christine Christensen
Eikeland, Randi
Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
title Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
title_full Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
title_fullStr Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
title_full_unstemmed Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
title_short Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
title_sort assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis
topic Original Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971095/
https://www.ncbi.nlm.nih.gov/pubmed/36380166
http://dx.doi.org/10.1007/s00415-022-11463-7
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