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The activation mechanism and antibody binding mode for orphan GPR20

GPR20 is a class-A orphan G protein-coupled receptor (GPCR) and a potential therapeutic target for gastrointestinal stromal tumors (GIST) owing to its differentially high expression. An antibody-drug conjugate (ADC) containing a GPR20-binding antibody (Ab046) was recently developed in clinical trial...

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Detalles Bibliográficos
Autores principales:	Lin, Xi, Jiang, Shan, Wu, Yiran, Wei, Xiaohu, Han, Gye-Won, Wu, Lijie, Liu, Junlin, Chen, Bo, Zhang, Zhibin, Zhao, Suwen, Cherezov, Vadim, Xu, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971246/ https://www.ncbi.nlm.nih.gov/pubmed/36849514 http://dx.doi.org/10.1038/s41421-023-00520-8

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