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Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord
The nervous system of the Asteroidea (starfish or seastar) consists of radial nerve cords (RNCs) that interconnect with a ring nerve. Despite its relative simplicity, it facilitates the movement of multiple arms and numerous tube feet, as well as regeneration of damaged limbs. Here, we investigated...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971248/ https://www.ncbi.nlm.nih.gov/pubmed/36849815 http://dx.doi.org/10.1038/s41598-023-30425-1 |
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author | Smith, Meaghan K. Rotgans, Bronwyn A. Lang, Tomas Johnston, Ryan Wang, Tianfang Suwansa-ard, Saowaros Bose, Utpal Satoh, Nori Egertova, Michaela Hall, Michael R. Byrne, Maria Elphick, Maurice R. Motti, Cherie A. Cummins, Scott F. |
author_facet | Smith, Meaghan K. Rotgans, Bronwyn A. Lang, Tomas Johnston, Ryan Wang, Tianfang Suwansa-ard, Saowaros Bose, Utpal Satoh, Nori Egertova, Michaela Hall, Michael R. Byrne, Maria Elphick, Maurice R. Motti, Cherie A. Cummins, Scott F. |
author_sort | Smith, Meaghan K. |
collection | PubMed |
description | The nervous system of the Asteroidea (starfish or seastar) consists of radial nerve cords (RNCs) that interconnect with a ring nerve. Despite its relative simplicity, it facilitates the movement of multiple arms and numerous tube feet, as well as regeneration of damaged limbs. Here, we investigated the RNC ultrastructure and its molecular components within the of Pacific crown-of-thorns starfish (COTS; Acanthaster sp.), a well-known coral predator that in high-density outbreaks has major ecological impacts on coral reefs. We describe the presence of an array of unique small bulbous bulbs (40–100 μm diameter) that project from the ectoneural region of the adult RNC. Each comprise large secretory-like cells and prominent cilia. In contrast, juvenile COTS and its congener Acanthaster brevispinus lack these features, both of which are non-corallivorous. Proteomic analysis of the RNC (and isolated neural bulbs) provides the first comprehensive echinoderm protein database for neural tissue, including numerous secreted proteins associated with signalling, transport and defence. The neural bulbs contained several neuropeptides (e.g., bombyxin-type, starfish myorelaxant peptide, secretogranin 7B2-like, Ap15a-like, and ApNp35) and Deleted in Malignant Brain Tumor 1-like proteins. In summary, this study provides a new insight into the novel traits of COTS, a major pest on coral reefs, and a proteomics resource that can be used to develop (bio)control strategies and understand molecular mechanisms of regeneration. |
format | Online Article Text |
id | pubmed-9971248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99712482023-03-01 Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord Smith, Meaghan K. Rotgans, Bronwyn A. Lang, Tomas Johnston, Ryan Wang, Tianfang Suwansa-ard, Saowaros Bose, Utpal Satoh, Nori Egertova, Michaela Hall, Michael R. Byrne, Maria Elphick, Maurice R. Motti, Cherie A. Cummins, Scott F. Sci Rep Article The nervous system of the Asteroidea (starfish or seastar) consists of radial nerve cords (RNCs) that interconnect with a ring nerve. Despite its relative simplicity, it facilitates the movement of multiple arms and numerous tube feet, as well as regeneration of damaged limbs. Here, we investigated the RNC ultrastructure and its molecular components within the of Pacific crown-of-thorns starfish (COTS; Acanthaster sp.), a well-known coral predator that in high-density outbreaks has major ecological impacts on coral reefs. We describe the presence of an array of unique small bulbous bulbs (40–100 μm diameter) that project from the ectoneural region of the adult RNC. Each comprise large secretory-like cells and prominent cilia. In contrast, juvenile COTS and its congener Acanthaster brevispinus lack these features, both of which are non-corallivorous. Proteomic analysis of the RNC (and isolated neural bulbs) provides the first comprehensive echinoderm protein database for neural tissue, including numerous secreted proteins associated with signalling, transport and defence. The neural bulbs contained several neuropeptides (e.g., bombyxin-type, starfish myorelaxant peptide, secretogranin 7B2-like, Ap15a-like, and ApNp35) and Deleted in Malignant Brain Tumor 1-like proteins. In summary, this study provides a new insight into the novel traits of COTS, a major pest on coral reefs, and a proteomics resource that can be used to develop (bio)control strategies and understand molecular mechanisms of regeneration. Nature Publishing Group UK 2023-02-27 /pmc/articles/PMC9971248/ /pubmed/36849815 http://dx.doi.org/10.1038/s41598-023-30425-1 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Smith, Meaghan K. Rotgans, Bronwyn A. Lang, Tomas Johnston, Ryan Wang, Tianfang Suwansa-ard, Saowaros Bose, Utpal Satoh, Nori Egertova, Michaela Hall, Michael R. Byrne, Maria Elphick, Maurice R. Motti, Cherie A. Cummins, Scott F. Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord |
title | Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord |
title_full | Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord |
title_fullStr | Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord |
title_full_unstemmed | Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord |
title_short | Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster sp.) radial nerve cord |
title_sort | structure and proteomic analysis of the crown-of-thorns starfish (acanthaster sp.) radial nerve cord |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971248/ https://www.ncbi.nlm.nih.gov/pubmed/36849815 http://dx.doi.org/10.1038/s41598-023-30425-1 |
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