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Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer?
Mucosal-associated invariant T (MAIT) cells are a subset of innate T lymphocytes that express the semi-invariant T cell receptor and recognize riboflavin metabolites via the major histocompatibility complex class I–related protein. Given the abundance of MAIT cells in the human body, their role in h...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971522/ https://www.ncbi.nlm.nih.gov/pubmed/36584816 http://dx.doi.org/10.1016/j.jcmgh.2022.12.014 |
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author | Zhang, Hejiao Shen, Haiyuan Zhou, Liangliang Xie, Linxi Kong, Derun Wang, Hua |
author_facet | Zhang, Hejiao Shen, Haiyuan Zhou, Liangliang Xie, Linxi Kong, Derun Wang, Hua |
author_sort | Zhang, Hejiao |
collection | PubMed |
description | Mucosal-associated invariant T (MAIT) cells are a subset of innate T lymphocytes that express the semi-invariant T cell receptor and recognize riboflavin metabolites via the major histocompatibility complex class I–related protein. Given the abundance of MAIT cells in the human body, their role in human diseases has been increasingly studied in recent years. MAIT cells may serve as targets for clinical therapy. Specifically, this review discusses how MAIT cells are altered in gastric, esophageal, intestinal, and hepatobiliary diseases and describes their protective or pathogenic roles. A greater understanding of MAIT cells will provide a more favorable therapeutic approach for digestive diseases in the clinical field. |
format | Online Article Text |
id | pubmed-9971522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99715222023-03-01 Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? Zhang, Hejiao Shen, Haiyuan Zhou, Liangliang Xie, Linxi Kong, Derun Wang, Hua Cell Mol Gastroenterol Hepatol Review Mucosal-associated invariant T (MAIT) cells are a subset of innate T lymphocytes that express the semi-invariant T cell receptor and recognize riboflavin metabolites via the major histocompatibility complex class I–related protein. Given the abundance of MAIT cells in the human body, their role in human diseases has been increasingly studied in recent years. MAIT cells may serve as targets for clinical therapy. Specifically, this review discusses how MAIT cells are altered in gastric, esophageal, intestinal, and hepatobiliary diseases and describes their protective or pathogenic roles. A greater understanding of MAIT cells will provide a more favorable therapeutic approach for digestive diseases in the clinical field. Elsevier 2022-12-27 /pmc/articles/PMC9971522/ /pubmed/36584816 http://dx.doi.org/10.1016/j.jcmgh.2022.12.014 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Hejiao Shen, Haiyuan Zhou, Liangliang Xie, Linxi Kong, Derun Wang, Hua Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? |
title | Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? |
title_full | Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? |
title_fullStr | Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? |
title_full_unstemmed | Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? |
title_short | Mucosal-Associated Invariant T Cells in the Digestive System: Defender or Destroyer? |
title_sort | mucosal-associated invariant t cells in the digestive system: defender or destroyer? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971522/ https://www.ncbi.nlm.nih.gov/pubmed/36584816 http://dx.doi.org/10.1016/j.jcmgh.2022.12.014 |
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