Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma

BACKGROUND: Somatic pathogenic variants (PVs) in homologous recombination DNA repair (HR)-related genes found in high-grade serous ovarian carcinomas (HGSC) are not well-characterised in older patients (≥70 years). This may reflect low testing rates in older patients. METHODS: Data from 1210 HGSC pa...

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Detalles Bibliográficos
Autores principales: Pitiyarachchi, Omali, Lee, Yeh Chen, Sim, Hao-Wen, Srirangan, Sivatharsny, Mapagu, Cristina, Kirk, Judy, Harnett, Paul R., Balleine, Rosemary L., Bowtell, David D.L., Samimi, Goli, Brand, Alison H., Marsh, Deborah J., Beale, Philip, Anderson, Lyndal, Bouantoun, Natalie, Provan, Pamela, Ramus, Susan J., DeFazio, Anna, Friedlander, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971549/
https://www.ncbi.nlm.nih.gov/pubmed/36805919
http://dx.doi.org/10.1016/j.tranon.2023.101638

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