Metabolic insights into phosphofructokinase inhibition in bloodstream-form trypanosomes

Previously, we reported the development of novel small molecules that are potent inhibitors of the glycolytic enzyme phosphofructokinase (PFK) of Trypanosoma brucei and related protists responsible for serious diseases in humans and domestic animals. Cultured bloodstream-form trypanosomes, which are...

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Detalles Bibliográficos
Autores principales: Nare, Zandile, Moses, Tessa, Burgess, Karl, Schnaufer, Achim, Walkinshaw, Malcolm D., Michels, Paul A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971811/
https://www.ncbi.nlm.nih.gov/pubmed/36864883
http://dx.doi.org/10.3389/fcimb.2023.1129791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971811/
https://www.ncbi.nlm.nih.gov/pubmed/36864883
http://dx.doi.org/10.3389/fcimb.2023.1129791

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