Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data

An existing physiologically based pharmacokinetic model for Di-(2-propylheptyl) phthalate (DPHP) was refined to improve the simulations of the venous blood concentrations of the primary monoester metabolite, mono-(2-propylheptyl) phthalate (MPHP). This was considered a significant deficiency that sh...

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Detalles Bibliográficos
Autores principales: McNally, Kevin, Loizou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971821/
https://www.ncbi.nlm.nih.gov/pubmed/36865923
http://dx.doi.org/10.3389/fphar.2023.1111433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971821/
https://www.ncbi.nlm.nih.gov/pubmed/36865923
http://dx.doi.org/10.3389/fphar.2023.1111433

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