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Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunction...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971823/ https://www.ncbi.nlm.nih.gov/pubmed/36866037 http://dx.doi.org/10.1016/j.isci.2022.105922 |
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author | Liu, Huifang Zhang, KeLun Jang, Yoon Ok Qiao, Zhen Jin, Jie Thi Dao, Thuy Nguyen Koo, Bonhan Park, Chang Ook Shin, Yong |
author_facet | Liu, Huifang Zhang, KeLun Jang, Yoon Ok Qiao, Zhen Jin, Jie Thi Dao, Thuy Nguyen Koo, Bonhan Park, Chang Ook Shin, Yong |
author_sort | Liu, Huifang |
collection | PubMed |
description | Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured Aspergillus extract (HI-AsE) and common agar-cultured Aspergillus extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis. |
format | Online Article Text |
id | pubmed-9971823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99718232023-03-01 Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses Liu, Huifang Zhang, KeLun Jang, Yoon Ok Qiao, Zhen Jin, Jie Thi Dao, Thuy Nguyen Koo, Bonhan Park, Chang Ook Shin, Yong iScience Article Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured Aspergillus extract (HI-AsE) and common agar-cultured Aspergillus extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis. Elsevier 2023-01-11 /pmc/articles/PMC9971823/ /pubmed/36866037 http://dx.doi.org/10.1016/j.isci.2022.105922 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Huifang Zhang, KeLun Jang, Yoon Ok Qiao, Zhen Jin, Jie Thi Dao, Thuy Nguyen Koo, Bonhan Park, Chang Ook Shin, Yong Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
title | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
title_full | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
title_fullStr | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
title_full_unstemmed | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
title_short | Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses |
title_sort | homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of aspergillus against hypersensitivity responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971823/ https://www.ncbi.nlm.nih.gov/pubmed/36866037 http://dx.doi.org/10.1016/j.isci.2022.105922 |
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