Cargando…

Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses

Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunction...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Huifang, Zhang, KeLun, Jang, Yoon Ok, Qiao, Zhen, Jin, Jie, Thi Dao, Thuy Nguyen, Koo, Bonhan, Park, Chang Ook, Shin, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971823/
https://www.ncbi.nlm.nih.gov/pubmed/36866037
http://dx.doi.org/10.1016/j.isci.2022.105922
_version_ 1784898184084979712
author Liu, Huifang
Zhang, KeLun
Jang, Yoon Ok
Qiao, Zhen
Jin, Jie
Thi Dao, Thuy Nguyen
Koo, Bonhan
Park, Chang Ook
Shin, Yong
author_facet Liu, Huifang
Zhang, KeLun
Jang, Yoon Ok
Qiao, Zhen
Jin, Jie
Thi Dao, Thuy Nguyen
Koo, Bonhan
Park, Chang Ook
Shin, Yong
author_sort Liu, Huifang
collection PubMed
description Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured Aspergillus extract (HI-AsE) and common agar-cultured Aspergillus extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis.
format Online
Article
Text
id pubmed-9971823
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-99718232023-03-01 Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses Liu, Huifang Zhang, KeLun Jang, Yoon Ok Qiao, Zhen Jin, Jie Thi Dao, Thuy Nguyen Koo, Bonhan Park, Chang Ook Shin, Yong iScience Article Fungi cause various forms of invasive fungal disease (IFD), and fungal sensitization can contribute to the development of asthma, asthma severity, and other hypersensitivity diseases, such as atopic dermatitis (AD). In this study, we introduce a facile and controllable approach, using homobifunctional imidoester-modified zinc nano-spindle (HINS), for attenuating hyphae growth of fungi and reducing the hypersensitivity response complications in fungi-infected mice. To extend the study of the specificity and immune mechanisms, we used HINS-cultured Aspergillus extract (HI-AsE) and common agar-cultured Aspergillus extract (Con-AsE) as the refined mouse models. HINS composites within the safe concentration range inhibited the hyphae growth of fungi but also reduce the number of fungal pathogens. Through the evaluation of lung and skin tissues from the mice, asthma pathogenesis (lung) and the hypersensitivity response (skin) to invasive aspergillosis were least severe in HI-AsE-infected mice. Therefore, HINS composites attenuate asthma and the hypersensitivity response to invasive aspergillosis. Elsevier 2023-01-11 /pmc/articles/PMC9971823/ /pubmed/36866037 http://dx.doi.org/10.1016/j.isci.2022.105922 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Huifang
Zhang, KeLun
Jang, Yoon Ok
Qiao, Zhen
Jin, Jie
Thi Dao, Thuy Nguyen
Koo, Bonhan
Park, Chang Ook
Shin, Yong
Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
title Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
title_full Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
title_fullStr Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
title_full_unstemmed Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
title_short Homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of Aspergillus against hypersensitivity responses
title_sort homobifunctional imidoester-modified zinc nano-spindle attenuated hyphae growth of aspergillus against hypersensitivity responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971823/
https://www.ncbi.nlm.nih.gov/pubmed/36866037
http://dx.doi.org/10.1016/j.isci.2022.105922
work_keys_str_mv AT liuhuifang homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT zhangkelun homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT jangyoonok homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT qiaozhen homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT jinjie homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT thidaothuynguyen homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT koobonhan homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT parkchangook homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses
AT shinyong homobifunctionalimidoestermodifiedzincnanospindleattenuatedhyphaegrowthofaspergillusagainsthypersensitivityresponses